Dynamic 1H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma

Oncotarget
Tong TongZhenwei Yao

Abstract

To determine whether the changes of [Cho/NAA] ratio in patients with glioma, measured by dynamic 1H-MRS can be used to differentiate between high-grade and low-grade gliomas. This prospective study was approved by the institutional ethics committee. Written informed consent was obtained. Forty-nine patients with biopsy-proven glioma and 20 normal control subjects were recruited in this study. The maximum [Cho/NAA] ratios, acquired at 0 min, and at 6 min, were calculated and assessed from volume of interests (VOI) in the tumor areas and in the surrounding normal tissue for each patient. Absolute difference in the [Cho/NAA] ratios, from MRS acquired at 0 and 6 min, in high-grade glioma, low-grade glioma, and control subjects were compared. The maximum [Cho/NAA] ratio acquired from the tumor area at the 0 min is 6.08 ± 2.02, which was significantly different (p = .017) from that acquired after 6 min, 4.87 ± 2.13. The [Cho/NAA] ratio from the surrounding normal tissue area did not change significantly from spectra acquired at different times (0 min, 6 min). Absolute difference in [Cho/NAA] ratios acquired at 0 and 6 min time points were significantly higher (P < 0.001) in high-grade glioma (= 3.86 ± 3.31) than in low-grade glioma (...Continue Reading

References

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Nov 24, 2005·Bioelectromagnetics·Sachiko YamaguchiShoogo Ueno

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Citations

Nov 12, 2016·Journal of Neurosurgery·Matthew Grech-SollarsAdam D Waldman
Apr 1, 2018·Molecular Carcinogenesis·Jie ShenHua Zhao
Sep 27, 2019·Frontiers in Neurology·Chenxi LiuYukui Wei
Dec 19, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xvlei HuHui Ma
Jun 26, 2021·Pathology, Research and Practice·Seyed Hamed JafariMajid Nejati

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Syngo

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