Abstract
We study the dynamics of a model that describes the competitive interaction between an invading species (a parasite) and its antibodies in an living being. This model was recently used to examine the dynamical competition between Tripanosoma cruzi and its antibodies during the acute phase of Chagas' disease. Depending on the antibody properties, the model yields three types of outcomes, corresponding, respectively, to healing, chronic disease, and host death. Here, we study the dynamics of the parasite-antibody interaction with the help of simulations, obtaining phase trajectories and phase diagrams for the system. We show that, under certain conditions, the size of the parasite inoculation can be crucial for the infection outcome and that a retardation in the stimulated production of an antibody species may result in the parasite gaining a definitive advantage. We also find a criterion for the relative sizes of the parameters that are required if parasite-generated decoys are indeed to help the invasion. Decoys may also induce a qualitatively different outcome: a limit cycle for the antibody-parasite population phase trajectories.
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Mar 30, 2010·Bio Systems·Viviane Galvão, José Garcia Vivas Miranda
Sep 23, 2008·Journal of Theoretical Biology·Hugo DevillersFrédéric Menu
Mar 24, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G J SibonaS Cossy Isasi
Jul 19, 2008·Bioinformatics·Viviane GalvãoRicardo Ribeiro-dos-Santos
Sep 14, 2013·Journal of Theoretical Biology·S P Vega Royero, G J Sibona