Dynamic anchoring transitions at aqueous-liquid crystal interfaces induced by specific and non-specific binding of vesicles to proteins

Journal of Colloid and Interface Science
Lie Na Tan, Nicholas L Abbott

Abstract

This paper reports on the dynamics of continuous anchoring transitions at interfaces formed between nematic liquid crystals (LCs, 4'-pentyl-4-cyanobiphenyl (5CB)) and immiscible aqueous phases that are induced by either non-specific or specific interactions between phospholipid vesicles and proteins adsorbed at the LC interfaces. By analyzing the dynamic response of LCs to non-specific adsorption of lipids onto bovine serum albumin (BSA)-decorated LC interfaces, we provide evidence that the LC anchoring transitions are slower than diffusion-controlled accumulation of lipid at the interface, consistent with the hypothesis that the LC transition involves lateral reorganization of proteins and lipids at the interface. Significantly, optical measurements of the tilt angle of the LC as a function of the amount of lipid captured at the interface were found to be quantitatively consistent with theoretical predictions of LC anchoring directed by nanoscopic domains of molecules that cause planar (protein) and homeotropic (lipid) anchoring of the LC. Finally, specific binding interactions between the antibody-decorated LC interfaces and vesicles (through antibody-antigen recognition) greatly accelerated the continuous LC anchoring transi...Continue Reading

References

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Citations

May 7, 2016·Environmental Science & Technology·Feng Xiao, Joseph J Pignatello
Jan 20, 2018·Physical Review. E·Shun Okushima, Toshihiro Kawakatsu
Aug 16, 2018·Soft Matter·Jenieve CumberlandAntal Jákli
Jul 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Piotr PopovAntal Jákli
Jun 21, 2017·Soft Matter·Pardis RofouieAlejandro D Rey

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