PMID: 7542467Apr 1, 1995Paper

Dynamic and differential Oct-1 expression during early Xenopus embryogenesis: persistence of Oct-1 protein following down-regulation of the RNA

Mechanisms of Development
G J VeenstraO H Destrée

Abstract

As a first step towards the elucidation of the role of the transcription factor Oct-1 in development, we prepared a monoclonal antibody to study the spatio-temporal distribution of Oct-1 protein in vivo. Here we report differential expression of the Oct-1 gene in the Xenopus embryo both at the RNA and the protein level. Transcripts and protein are detected in ectodermal and mesodermal cell lineages, in which the expression exhibits a pattern of progressive spatial restriction in the course of development. The Oct-1 expression as reported here is not correlated with cell density or cell proliferation in the embryo. Our results suggest a role of Oct-1 in the specification and differentiation of neuronal and neural crest cells. In many other cells, the developmental decision to down regulate Oct-1 is delayed, probably due to a high stability of the protein.

References

Aug 1, 1992·Journal of Virology·M CareyG Miller
Dec 16, 1992·Biochimica Et Biophysica Acta·D Read, J L Manley
Feb 1, 1992·Molecular and Cellular Biology·R Aurora, W Herr
Feb 1, 1992·Molecular and Cellular Biology·C S HinkleyM Perry
Oct 1, 1991·Trends in Genetics : TIG·H R Schöler
Feb 1, 1991·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·C Campbell
Oct 24, 1991·Nature·S C Harrison
Mar 26, 1991·Biochimica Et Biophysica Acta·N Heintz
Jun 1, 1991·Genes & Development·M G Rosenfeld
Jan 25, 1990·Nucleic Acids Research·D P Smith, R W Old
Dec 8, 1988·Nature·R A Sturm, W Herr
Jan 1, 1995·Trends in Genetics : TIG·T L BeumerO H Destrée
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M R GerreroM G Rosenfeld
Nov 1, 1993·Trends in Genetics : TIG·J H Thomas
Aug 1, 1993·Molecular and Cellular Biology·D A DanzeiserG R Kunkel
Jan 23, 1993·Biochimica Et Biophysica Acta·F KambeH Seo

❮ Previous
Next ❯

Citations

Jun 20, 1997·Molecular and Cellular Endocrinology·T NagasawaL J DeGroot
Aug 3, 2005·Nucleic Acids Research·Tal OrenTodd Evans
Oct 21, 2010·Cellular and Molecular Life Sciences : CMLS·Yinan LiuChunyan Zhou
Dec 27, 1996·Annals of the New York Academy of Sciences·R A Roberts
Apr 23, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E Jean CornishChrista S Merzdorf
Nov 12, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bo YanSally A Moody
Jun 14, 2005·Developmental Biology·John S Reece-HoyesHarry V Isaacs
Aug 19, 2007·The EMBO Journal·Ulrike G JacobiGert Jan C Veenstra
Jul 25, 1998·Journal of Biomedical Science·S VenanziP A Battaglia
Mar 1, 1996·Mechanisms of Development·S SteinM Kessel
Jul 11, 2003·Immunology Letters·Elizaveta V PankratovaIvan V Krivega
Sep 24, 2021·Scientific Reports·Alexander G StepchenkoElizaveta V Pankratova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved