Dynamic and programmable morphology and size evolution via a living hierarchical self-assembly strategy

Nature Communications
Xing WangDecheng Wu

Abstract

Recent advances in the preparation of shape-shifting and size-growing nanostructures are hot topics in development of nanoscience, because many intelligent functions are always relied on their shape and dimension. Here we report a tunable manipulation of sequential self-assembled transformation in situ via a hierarchical assembly strategy based on a living thiol-disulfide exchange reaction. By tailoring the external stimuli, the reactive points can be generated at the ends of initially unimolecular micelles, which subsequently drive the pre-assemblies to periodically proceed into the hierarchically micellar connection, axial growth, bending, and cyclization processes from nanoscopic assemblies to macroscopic particles. Of particular interest would be systems that acquired the shape control and size adjustment of self-assemblies after termination or reactivation of disulfide reshuffling reaction by regulating external stimuli whenever needed. Such a hierarchical strategy for self-assembled evolution is universally applicable not only for other disulfide-linked dendritic polymers but also for exploitation of biological applications.

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Citations

Sep 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong ChiJoshy K S
Mar 6, 2019·Biomaterials Science·Linfeng FanDecheng Wu
Jun 11, 2019·Biomaterials Science·Yuanhao ZhangWeian Zhang
Apr 9, 2020·Frontiers in Pharmacology·Daoyang FanZhongjun Liu
Mar 30, 2019·Nature Communications·Shu-Ping WangShijun Li
Jan 12, 2021·Frontiers in Bioengineering and Biotechnology·Mingming ZhangDawei Li
Feb 15, 2020·ACS Applied Materials & Interfaces·Feifei SunDecheng Wu
Sep 23, 2021·Science Advances·Artur KopitcaQuan Zhou
Oct 16, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Justine M KalawToshiyuki Kida

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Methods Mentioned

BETA
acylation
fluorescence spectroscopy
transmission electron microscopy

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