Dynamic and steady-state oxygen-dependent lung relaxometry using inversion recovery ultra-fast steady-state free precession imaging at 1.5 T

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Grzegorz BaumanOliver Bieri

Abstract

To demonstrate the feasibility of oxygen-dependent relaxometry in human lung using an inversion recovery ultra-fast steady-state free precession (IR-ufSSFP) technique. Electrocardiogram-triggered pulmonary relaxometry with IR-ufSSFP was performed in 7 healthy human subjects at 1.5 T. The data were acquired under both normoxic and hyperoxic conditions. In a single breath-hold of less than 9 seconds, 30 transient state IR-ufSSFP images were acquired, yielding longitudinal (T1) and transversal (T2) relaxometry parameter maps using voxel-wise nonlinear fitting. Possible spatial misalignments between consecutive IR-ufSSFP parameter maps were corrected using elastic image registration. Furthermore, dynamic relaxometry oxygen wash-in and wash-out scans were performed in one volunteer. From this, T1 -related wash-in and wash-out time constants (τwi , τwo ) were calculated voxel-wise on registered maps using an exponential fitting model. For healthy lung, observed T1 values were 1399 ± 77 and 1290 ± 76 ms under normoxic and hyperoxic conditions, respectively. Oxygen-related reduction of T1 was statistically significant in every volunteer. No statistically significant change, however, was observed in T2, with normoxic and hyperoxic T2 va...Continue Reading

References

Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·E TadamuraR R Edelman
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R LöfflerM Reiser
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mark A GriswoldAxel Haase
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter SchmittAxel Haase
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter M JakobDietbert Hahn
Apr 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Eberhard D PrachtPeter M Jakob
Aug 3, 2005·Respiratory Physiology & Neurobiology·Deokiee ChonEric A Hoffman
Aug 10, 2007·Journal of Magnetic Resonance Imaging : JMRI·Johannes F T ArnoldPeter M Jakob
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Riccarda FailoMaarten H Lequin
May 15, 2009·Computer Methods and Programs in Biomedicine·D MaleikeI Wolf
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grzegorz BaumanLothar R Schad
Jul 9, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Henrik PedersenWon Yong Kim
Mar 2, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Philipp EhsesVikas Gulani
Mar 12, 2013·Journal of Magnetic Resonance·David A Feinberg, Kawin Setsompop
Jun 1, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter KellmanMichael Schacht Hansen
Jul 3, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Oliver Bieri
Jul 22, 2014·Journal of Magnetic Resonance Imaging : JMRI·Simon M F TriphanPeter M Jakob
Aug 13, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Francesco SantiniO Bieri
Dec 4, 2014·European Journal of Radiology·Wei-Juan ZhangJosephine H Naish
May 9, 2015·Magnetic Resonance Imaging Clinics of North America·Justus E RoosBastiaan Driehuys
Jul 29, 2015·Journal of Magnetic Resonance Imaging : JMRI·Stanley J KrugerSean B Fain
Sep 4, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grzegorz Bauman, Oliver Bieri
Oct 21, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Grzegorz BaumanOliver Bieri

❮ Previous
Next ❯

Citations

Jan 31, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Heling ZhouRalph P Mason

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Grzegorz BaumanOliver Bieri
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Orso PusterlaOliver Bieri
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Orso PusterlaOliver Bieri
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Li AnJun Shen
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Yong ChenVikas Gulani
© 2022 Meta ULC. All rights reserved