Dynamic aphasia in progressive supranuclear palsy: a deficit in generating a fluent sequence of novel thought

Neuropsychologia
Gail RobinsonLisa Cipolotti

Abstract

We report a patient (KAS) who presented with pure dynamic aphasia in the context of progressive supranuclear palsy (PSP). KAS had the hallmark propositional language impairment in the context of preserved naming, reading, repetition and comprehension skills. The severity of KAS's propositional language deficit was demonstrated to be comparable to other dynamic aphasic patients. Remarkably, despite virtually abolished propositional speech, KAS was unimpaired on word and sentence level generation tasks that required a single response. This dissociation was further investigated on two discourse level generation tasks that required the generation of multiple connected sentences. Quantitative production analysis and novelty measures demonstrated that her performance was extremely reduced and characterised by a lack of novel words and sentences and a tendency to perseverate. This pattern of performance suggests that there may be two subtypes of dynamic aphasia. Patients with the more documented first subtype have language-specific deficits, fail word and sentence level generation tests and have left inferior frontal gyrus lesions. Patients with the second subtype, like KAS, pass word and sentence level generation tests and fail disco...Continue Reading

Citations

Oct 20, 2007·Brain : a Journal of Neurology·Jonathan D RohrerJason D Warren
Jun 12, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Antonio DanieleGuido Gainotti
Dec 28, 2011·Brain and Language·Shiao-Hui ChanThomas G Bever
Sep 8, 2009·Journal of the Neurological Sciences·Andrew Kertesz, Paul McMonagle
Jul 22, 2014·Neuropsychological Rehabilitation·Bonnie LawGail A Robinson
Jul 18, 2015·Journal of Communication Disorders·Jae-Hyun Kim, Clare M McCann
Apr 10, 2015·Journal of Alzheimer's Disease : JAD·Nicholas J Milano, Kenneth M Heilman
Jan 24, 2017·Brain and Language·Megan S BarkerGail A Robinson
May 22, 2018·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Daniel L MaddenGail A Robinson
Dec 20, 2017·Journal of Alzheimer's Disease : JAD·James R BurrellJohn R Hodges
Jul 18, 2018·Journal of Clinical and Experimental Neuropsychology·Daniel L MaddenGail A Robinson
Jan 5, 2019·Journal of Clinical and Experimental Neuropsychology·Megan S Barker, Gail A Robinson
May 17, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M SilsbyJ R Burrell
Nov 16, 2019·Journal of the International Neuropsychological Society : JINS·Megan S BarkerGail A Robinson
Apr 9, 2020·Frontiers in Human Neuroscience·Marcelo L BerthierDiana López-Barroso
Jul 20, 2019·Journal of Neurology·Katie A PetersonJames B Rowe
Aug 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Eleonora Del PreteRoberto Ceravolo
Dec 29, 2020·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Megan S BarkerGail A Robinson
Mar 3, 2021·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Megan S BarkerGail A Robinson
Oct 9, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Amelia CeslisGail A Robinson
Apr 4, 2021·Brain Sciences·Gail A RobinsonAmelia Ceslis
May 22, 2021·Frontiers in Aging Neuroscience·Marcelo L BerthierGuadalupe Dávila

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