PMID: 16640861Apr 28, 2006Paper

Dynamic assay of serum inhibin B and estradiol concentrations obtained after gonadotrophin therapy as predictors of ovarian response in vitro fertilization cycle

Zhonghua fu chan ke za zhi
Min-fang Miao, He-feng Huang

Abstract

To study prospectively the values of basal and dynamic measurement of inhibin B (INHB), estrodiol (E(2)) following gonadotrophin therapy in vitro fertilization (IVF) cycles in predicting ovarian response to stimulation in young women. A total of 57 patients younger than 40 years of age undergoing their first cycle of long protocol IVF treatment were studied and serum INHB, E(2) levels were detected on day 3 of the menstrual cycle, before the first administration of gonadotrophin (day 0), on days 1 and 5 after gonadotrophin therapy (day 1, day 5). Ovarian response was presented by: number of oocytes/total rFSH dose and square root of (number of follicles/total rFSH dose). According to number of follicles, number of oocytes and presence or absence of ovarian hyperstimulation syndrome (OHSS), we categorized the results into three different groups: poor response, normal response and OHSS. (1) Hormone levels on days 1, 5 of rFSH stimulation: There were positive correlation between INHB (r(S): 0.69 - 0.73), E(2) (r(S): 0.60 - 0.73) and ovarian response (P = 0.000). (2) INHB, and E(2) levels on day 5 of rFSH stimulation were significantly different between poor response, normal response and OHSS groups (P < 0.01), and INHB levels were...Continue Reading

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