Dynamic brain network states in human generalized spike-wave discharges.

Brain : a Journal of Neurology
Chayanin TangwiriyasakulMark P Richardson

Abstract

Generalized spike-wave discharges in idiopathic generalized epilepsy are conventionally assumed to have abrupt onset and offset. However, in rodent models, discharges emerge during a dynamic evolution of brain network states, extending several seconds before and after the discharge. In human idiopathic generalized epilepsy, simultaneous EEG and functional MRI shows cortical regions may be active before discharges, and network connectivity around discharges may not be normal. Here, in human idiopathic generalized epilepsy, we investigated whether generalized spike-wave discharges emerge during a dynamic evolution of brain network states. Using EEG-functional MRI, we studied 43 patients and 34 healthy control subjects. We obtained 95 discharges from 20 patients. We compared data from patients with discharges with data from patients without discharges and healthy controls. Changes in MRI (blood oxygenation level-dependent) signal amplitude in discharge epochs were observed only at and after EEG onset, involving a sequence of parietal and frontal cortical regions then thalamus (P < 0.01, across all regions and measurement time points). Examining MRI signal phase synchrony as a measure of functional connectivity between each pair of...Continue Reading

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Citations

Jun 5, 2019·Epilepsia·Astrid Nehlig, Michael Sperling
May 22, 2020·Brain : a Journal of Neurology·Vincenzo CrunelliFrançois David
Nov 10, 2020·International Journal of Neural Systems·Sisi JiangCheng Luo
May 5, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Adam M Goodman, Jerzy P Szaflarski
Aug 20, 2021·Frontiers in Neurology·Rory J PiperDavid W Carmichael
Nov 28, 2021·Nature Reviews. Neurology·Bernd J VorderwülbeckeMartin Holtkamp
Jan 25, 2022·Brain Topography·Muhammad Aamir PanhwarGhazala Panhwar

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