Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis

Oncotarget
Chung-Ji LiuWan-Chun Li

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. While numerous potent dietary insults were considered as oncogenic players for HNSCC development, the impact of metabolic imbalance was less emphasized during HNSCC carcinogenesis. Previous preclinical and epidemiological investigations showed that DM could possibly be correlated with greater incidence and poorer prognosis in HNSCC patients; however, the outcomes from different groups are contradictive and underlying mechanisms remains elusive. In the present study, the changes of cellular malignancy in response to prolonged glucose incubation in HNSCC cells were examined. The results demonstrated that hyperglycemia enhanced HNSCC cell malignancy over time through suppression of cell differentiation, promotion of cell motility, increased resistance to cisplatin, and up-regulation of the nutrient-sensing Akt/AMPK-mTORC1 pathway. Further analysis showed that a more aggressive tongue neoplastic progression was found under DM conditions compared to non-DM state whereas DM pathology led to a higher percentage of cervical lymph node metastasis and poorer prognosis in HNSCC patients. Taken together, the present study confirms that hyperglyc...Continue Reading

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Citations

May 13, 2017·Scientific Reports·Lan HePaul K S Chan
Sep 23, 2020·Biomolecules·Hsiang YangHsin-Ming Chen
Mar 21, 2020·Frontiers in Oncology·Wan-Chun LiKuo-Wei Chang
Aug 17, 2019·International Journal of Molecular Sciences·Yi-Ta HsiehWan-Chun Li
May 10, 2020·International Journal of Molecular Sciences·Choudhary HarshaAjaikumar B Kunnumakkara

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Methods Mentioned

BETA
surgical resection
Antibody Array
protein array
PCR

Software Mentioned

Image J
SPSS
GraphPad
Prism

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