Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes

Clinical and Experimental Immunology
Sanja Glisic-MilosavljevicSoumitra Ghosh


Because type 1 diabetes (T1D) is a chronic, autoimmune, T cell-mediated disease, interventions affecting T cells are expected to modulate the immune cascade and lead to disease remission. We propose that increased CD4(+) CD25(+high) T cell apoptosis, a trait we discovered in recent-onset T1D subjects, reflects T1D partial remission within the first 6 months after diagnosis. Apoptosis of forkhead box P3 (FoxP3)(+) CD4(+) CD25(+high) T cells, in addition to total daily doses of insulin (TDD), blood glucose, HbA1c and age, were measured in 45 subjects with T1D at various times after diagnosis. Sixteen healthy control subjects were also recruited to the study. Higher CD4(+) CD25(+high) T cell apoptosis levels were detected within the first 6 months of diagnosis (odds ratio = 1.39, P = 0.009), after adjustment for age, TDD and HbA1c. A proportional hazards model confirmed that the decline of apoptosis after diagnosis of T1D was related significantly to survival time (hazards ratio = 1.08, P = 0.014), with TDD and age also contributing to survival. During this time there was an inverse relationship between CD4(+) CD25(+high) T cell apoptosis with TDD (r = -0.39, P = 0.008). The CD4(+) CD25(+high) T cell apoptosis levels decline signi...Continue Reading


Mar 23, 1999·Archives of Disease in Childhood·B J MuhammadJ L Botha
May 1, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·E BöberA Büyükgebiz
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clare Baecher-AllanDavid A Hafler
Mar 5, 2003·Immunological Reviews·Harald von BoehmerLudger Klein
Mar 27, 2004·Pediatric Diabetes·H Peter ChaseMarian Rewers
Mar 27, 2004·BMJ : British Medical Journal·Devasenan DevendraG S Eisenbarth
Jul 22, 2004·Current Diabetes Reports·Mariela Glandt, Kevan C Herold
Aug 3, 2004·Nature Reviews. Immunology·Stephen P PerfettoMario Roederer
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe PoussierSheela Ramanathan
Jun 7, 2005·Diabetes Research and Clinical Practice·P PozzilliIMDIAB group


Jun 12, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Agnieszka SzypowskaW Luczynski
Mar 20, 2009·Genes and Immunity·Sanja GlisicSoumitra Ghosh
Jan 29, 2014·Nature Reviews. Endocrinology·Bart O Roep, Timothy I M Tree
Jul 6, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Norma Segovia-GamboaCarmen Sánchez-Torres
Aug 28, 2009·Trends in Endocrinology and Metabolism : TEM·Claire L Price, Stella C Knight
Aug 17, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gerlies TreiberThomas R Pieber
Jan 24, 2009·International Immunopharmacology·Eric R SecorRoger S Thrall
Aug 25, 2009·European Journal of Immunology·Srikanta JanaSoumitra Ghosh
Nov 29, 2008·Clinical and Experimental Immunology·J M LawsonTimothy I M Tree
Jul 11, 2008·Immunological Reviews·Sarah E AllanMegan K Levings
Jan 25, 2017·Journal of Autoimmunity·Caroline M HullTimothy I M Tree
Jul 26, 2019·Diabetes/metabolism Research and Reviews·Ting ZhongZhiguang Zhou
Aug 5, 2017·Diabetologia·Caroline M HullTimothy I M Tree
Dec 22, 2010·European Journal of Medical Research·Agnieszka SzypowskaW Luczynski
Feb 26, 2019·Frontiers in Immunology·Anna GrohováLenka Palová-Jelínková
Dec 11, 2020·JCI Insight·Aditi NarsaleJoanna D Davies

Related Concepts

Hemoglobin A1c protein, human
Diabetes, Autoimmune
Drug Administration Schedule
Hb A1a-2
Remission Induction
T-Lymphocyte Subsets
Apoptosis, Intrinsic Pathway
Tr1 Cells
Interleukin 2 Receptor, Alpha

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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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