Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine

Molecular Pain
Qing ZhangShengyuan Yu

Abstract

Migraine is the seventh most disabling disorder globally, with prevalence of 11.7% worldwide. One of the prevailing mechanisms is the activation of the trigeminovascular system, and calcitonin gene-related peptide (CGRP) is an important therapeutic target for migraine in this system. Recent studies suggested an emerging role of pituitary adenylate cyclase-activating peptide (PACAP) in migraine. However, the relation between CGRP and PACAP and the role of PACAP in migraine remain undefined. In this study, we established a novel repetitive (one, three, and seven days) electrical stimulation model by stimulating dura mater in conscious rats. Then, we determined expression patterns in the trigeminal ganglion and the trigeminal nucleus caudalis of the trigeminovascular system. Electrical stimulation decreased facial mechanical thresholds, and the order of sensitivity was as follows: vibrissal pad >inner canthus >outer canthus (P < 0.001). The electrical stimulation group exhibited head-turning and head-flicks (P < 0.05) nociceptive behaviors. Importantly, electrical stimulation increased the expressions of CGRP, PACAP, and the PACAP-preferring type 1 (PAC1) receptor in both trigeminal ganglion and trigeminal nucleus caudalis (P < 0....Continue Reading

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Citations

May 1, 2019·The Journal of Headache and Pain·Tamás KörtésiJános Tajti
Jun 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaobai XuLinpeng Wang
Jun 19, 2019·International Journal of Molecular Sciences·Giuseppe TardioloEmanuela Mazzon
Dec 31, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Qingyu YaoFengzeng Jian
Oct 26, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Rosaria GrecoCristina Tassorelli

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