Dynamic changes in computed tomography manifestations of 105 patients with novel coronavirus pneumonia in Wuhan, China

The Journal of International Medical Research
Yueying PanHanxiong Guan

Abstract

To observe the evolution of chest high-resolution computed tomography (HRCT) manifestations in 105 patients with coronavirus disease 2019 (COVID-19). One hundred five patients with confirmed COVID-19 were enrolled from 11 January to 9 February 2020. Sequential chest HRCT examinations were performed. Five stages were identified from the onset of initial symptoms: 0-3, 4-7, 8-14, 15-21, and >21 days (Stages A-E, respectively). A semi-quantitative CT scoring system was used to estimate the sum of lung abnormalities in each stage. In total, 393 CT scans were collected. The patients underwent 3.8 ± 1.5 CT examinations. Multiple lobes were involved in most cases. The proportion of consolidation and the total CT score gradually increased from Stage A to C and gradually decreased from Stage C to E. The total CT score of lung involvement was significantly higher in Stage C than in Stages B and D. The CT score of the lower lobe was significantly higher than the corresponding upper and middle lobes in Stages A to D. Most patients with COVID-19 had a disease course of >14 days, and the lung lesions in most patients improved after 14 days since initial symptom onset.

References

Jan 16, 2008·Radiology·David M HansellJacques Remy
Nov 26, 2009·AJR. American Journal of Roentgenology·Daniel J MolluraDavid A Bluemke
Jan 19, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David S HuiEskild Petersen
Jan 23, 2020·Journal of Medical Virology·Yu ChenDeyin Guo
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 7, 2020·European Radiology·Yueying Pan, Hanxiong Guan
Feb 8, 2020·Military Medical Research·Ying-Hui JinUNKNOWN , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chap
Feb 8, 2020·JAMA : the Journal of the American Medical Association·Dawei WangZhiyong Peng
Apr 16, 2020·European Radiology·Ting LiangJian Yang

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