Dynamic changes in interneuron morphophysiological properties mark the maturation of hippocampal network activity.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Camille AlleneRosa Cossart

Abstract

During early postnatal development, neuronal networks successively produce various forms of spontaneous patterned activity that provide key signals for circuit maturation. Initially, in both rodent hippocampus and neocortex, coordinated activity emerges in the form of synchronous plateau assemblies (SPAs) that are initiated by sparse groups of gap-junction-coupled oscillating neurons. Subsequently, SPAs are replaced by synapse-driven giant depolarizing potentials (GDPs). Whether these sequential changes in mechanistically distinct network activities correlate with modifications in single-cell properties is unknown. To determine this, we studied the morphophysiological fate of single SPA cells as a function of development. We focused on CA3 GABAergic interneurons, which are centrally involved in generating GDPs in the hippocampus. As the network matures, GABAergic neurons are engaged more in GDPs and less in SPAs. Using inducible genetic fate mapping, we show that the individual involvement of GABAergic neurons in SPAs is correlated to their temporal origin. In addition, we demonstrate that the SPA-to-GDP transition is paralleled by a remarkable maturation in the morphophysiological properties of GABAergic neurons. Compared with...Continue Reading

References

Apr 1, 1991·Journal of Neuroscience Methods·L StoppiniD Muller
Jul 24, 1998·Science·S M Catalano, C J Shatz
Jul 18, 2003·Journal of Neurophysiology·Roman TyzioRoustem Khazipov
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qing XuStewart A Anderson
Jan 7, 2005·Anatomical Science International·Robert R Buss, Ronald W Oppenheim
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sampsa T SipiläKai Kaila
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
May 23, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Doris D Wang, Arnold R Kriegstein
Jun 24, 2008·Nature Reviews. Neuroscience·UNKNOWN Petilla Interneuron Nomenclature GroupRafael Yuste
Nov 4, 2008·Nature·Milan Petrovic, Thomas Hummel
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Camille AllèneRosa Cossart
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel DoischerMarlene Bartos
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carsten K PfefferChristian A Hübner
May 12, 2009·Current Topics in Developmental Biology·Renata Batista-Brito, Gord Fishell
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin W OkatySacha B Nelson
Dec 3, 2009·Nature Reviews. Neuroscience·Aaron G Blankenship, Marla B Feller
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Goichi MiyoshiGord Fishell
Oct 23, 2010·Cerebral Cortex·Antje GolbsHeiko J Luhmann
Apr 8, 2011·Annual Review of Neuroscience·Gord Fishell, Bernardo Rudy
Apr 13, 2011·Developmental Neurobiology·Joshua G Corbin, Simon J B Butt
Jul 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ludovic TricoireChris J McBain

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Citations

May 18, 2013·Cerebral Cortex·Jian MaYong-Chun Yu
Jan 19, 2016·The Journal of Comparative Neurology·Vincent VilletteAgnès Baude
Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Apr 28, 2020·Journal of the International Neuropsychological Society : JINS·Cassandra L HendrixJuliet Haarbauer-Krupa
Jul 20, 2021·Physiological Reviews·Rosa Cossart, Roustem Khazipov

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