Abstract
Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multiple in vivo models including the fate mapping of inhibitor of DNA binding-2 (Id2) expression and the use of Id2 reporter mice. Our data demonstrate that ILCs are more prominent immediately after birth, but were rapidly diluted as the T-cell development program increased. As observed in the embryonic thymus, CCR6+ NKp46- lymphoid tissue inducer (LTi) cells were the main ILC3 population present, but numbers of these cells swiftly declined in the neonate and ILC3 were barely detectable in adult thymus. This loss of ILC3 means ILC2 are the dominant ILC population in the thymus. Thymic ILC2 were able to produce IL-5 and IL-13, were located within the medulla, and did not result from ILC3 plasticity. Furthermore, in WT mice, thymic ILC2 express little RANKL (receptor activator of nuclear factor kappa-B ligand) arguing that functionally, these cells provide different signals to LTi cells in the thymus. Collectively, these ...Continue Reading
References
Nov 19, 1992·Nature·P MombaertsM L Hooper
Jul 6, 2000·Science·Z SunD R Littman
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·T IkawaY Yokota
Sep 13, 2003·Immunological Reviews·Gerard Eberl, Dan R Littman
Jul 13, 2004·Science·Gérard Eberl, Dan R Littman
Dec 16, 2006·European Journal of Immunology·Hervé LucheHans Jörg Fehling
May 16, 2007·The Journal of Experimental Medicine·Simona W RossiGraham Anderson
Sep 18, 2007·Genesis : the Journal of Genetics and Development·Mandar Deepak MuzumdarLiqun Luo
Apr 22, 2008·Nature Immunology·Elke ScandellaBurkhard Ludewig
Sep 19, 2008·Immunity·Taishin AkiyamaJun-Ichiro Inoue
Sep 19, 2008·Immunity·Yu HikosakaYousuke Takahama
Oct 27, 2009·Development·Emma L RawlinsBrigid L M Hogan
Aug 14, 2010·Nature Reviews. Immunology·Serge A van de Pavert, Reina E Mebius
May 19, 2011·The EMBO Journal·Jacob T JacksonGabrielle T Belz
Jan 24, 2012·Nature Immunology·See Heng WongAndrew N J McKenzie
Mar 3, 2012·Science·Jarrod A DudakovMarcel R M van den Brink
Mar 20, 2012·Immunity·Natalie A RobertsGraham Anderson
Jan 22, 2013·Nature·Christoph S N KloseAndreas Diefenbach
Jan 26, 2013·Nature Reviews. Immunology·Hergen SpitsEric Vivier
May 24, 2013·Nature·Matthew R HepworthGregory F Sonnenberg
Oct 25, 2013·Frontiers in Immunology·Rebecca GentekDerk Amsen
Feb 11, 2014·Nature·Michael G ConstantinidesAlbert Bendelac
Apr 15, 2014·Cell·Christoph S N KloseAndreas Diefenbach
Aug 5, 2014·Immunity·Christopher J OliphantAndrew N J McKenzie
Jan 13, 2015·Nature Communications·Emma C MackleyDavid R Withers
Jan 17, 2015·Nature·David Artis, Hergen Spits
Feb 23, 2017·Annual Review of Immunology·Jakub Abramson, Graham Anderson
Mar 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong-Cheng WangXiao-Hong Sun
May 18, 2017·Immunity·Masaki MiyazakiCornelis Murre
Jul 12, 2017·The Journal of Experimental Medicine·Andrea J WhiteGraham Anderson
Citations
Sep 5, 2018·European Journal of Immunology·Tom Cupedo
Jun 9, 2019·Science Immunology·Franz PutturClare M Lloyd
Oct 3, 2019·Cellular and Molecular Life Sciences : CMLS·Max Van BelkumJosef Neu
Mar 23, 2019·The Journal of Experimental Medicine·Liangyue QianXiao-Hong Sun
Oct 9, 2018·Immunological Reviews·Francisca F AlmeidaGabrielle T Belz
Jan 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Maria EnnamoratiNitya Jain
Aug 15, 2018·Frontiers in Immunology·Jack C YuBabak Baban
Aug 28, 2020·Frontiers in Cellular Neuroscience·Aura ZelcoXiaoyang Wang
May 28, 2020·Frontiers in Immunology·Abdullah S AlawamBeth Lucas
Jun 20, 2020·Journal of Leukocyte Biology·V Kumar
Jan 16, 2021·Seminars in Immunopathology·Yujun DengHongbo Hu
Jan 16, 2021·Trends in Immunology·Chen LiuHongbo Hu
Jan 18, 2021·Experimental Hematology·Ellen V Rothenberg
Jan 13, 2021·Nature Immunology·Ana C F FerreiraAndrew N J McKenzie
Oct 8, 2020·Blood·Ramy ElsaidAna Cumano
May 28, 2019·Current Opinion in Immunology·Nicholas A SpidaleJoonsoo Kang
Mar 19, 2021·International Reviews of Immunology·Vijay Kumar
May 25, 2021·Frontiers in Immunology·Samuel B Shin, Kelly M McNagny
Jul 10, 2021·Cell Research·Chen LiuBing Liu
Feb 1, 2022·Trends in Immunology·Scarlett E LeeNorah L Smith