Dynamic changes in intrathymic ILC populations during murine neonatal development.

European Journal of Immunology
Rhys JonesDavid Withers

Abstract

Members of the innate lymphoid cell (ILC) family have been implicated in the development of thymic microenvironments and the recovery of this architecture after damage. However, a detailed characterization of this family in the thymus is lacking. To better understand the thymic ILC compartment, we have utilized multiple in vivo models including the fate mapping of inhibitor of DNA binding-2 (Id2) expression and the use of Id2 reporter mice. Our data demonstrate that ILCs are more prominent immediately after birth, but were rapidly diluted as the T-cell development program increased. As observed in the embryonic thymus, CCR6+ NKp46- lymphoid tissue inducer (LTi) cells were the main ILC3 population present, but numbers of these cells swiftly declined in the neonate and ILC3 were barely detectable in adult thymus. This loss of ILC3 means ILC2 are the dominant ILC population in the thymus. Thymic ILC2 were able to produce IL-5 and IL-13, were located within the medulla, and did not result from ILC3 plasticity. Furthermore, in WT mice, thymic ILC2 express little RANKL (receptor activator of nuclear factor kappa-B ligand) arguing that functionally, these cells provide different signals to LTi cells in the thymus. Collectively, these ...Continue Reading

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Citations

Sep 5, 2018·European Journal of Immunology·Tom Cupedo
Oct 3, 2019·Cellular and Molecular Life Sciences : CMLS·Max Van BelkumJosef Neu
Mar 23, 2019·The Journal of Experimental Medicine·Liangyue QianXiao-Hong Sun
Oct 9, 2018·Immunological Reviews·Francisca F AlmeidaGabrielle T Belz
Jan 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Maria EnnamoratiNitya Jain
Aug 15, 2018·Frontiers in Immunology·Jack C YuBabak Baban
May 28, 2020·Frontiers in Immunology·Abdullah S AlawamBeth Lucas
Jan 16, 2021·Seminars in Immunopathology·Yujun DengHongbo Hu
Jan 16, 2021·Trends in Immunology·Chen LiuHongbo Hu
Jan 13, 2021·Nature Immunology·Ana C F FerreiraAndrew N J McKenzie
May 28, 2019·Current Opinion in Immunology·Nicholas A SpidaleJoonsoo Kang
May 25, 2021·Frontiers in Immunology·Samuel B Shin, Kelly M McNagny
Feb 1, 2022·Trends in Immunology·Scarlett E LeeNorah L Smith

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Methods Mentioned

BETA
flow cytometry
FACS

Software Mentioned

Graphpad Prism
FlowJo

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