Dynamic Changes in Nociception and Pain Perception After Spinal Cord Stimulation in Chronic Neuropathic Pain Patients

The Clinical Journal of Pain
José A Biurrun ManresaBjörn Gerdle

Abstract

Patients with an implanted spinal cord stimulation (SCS) system for pain management present an opportunity to study dynamic changes in the pain system in a situation where patients are not stimulated (ie, experiencing severe pain) compared with a situation in which patients have just been stimulated (ie, pain free or greatly reduced pain). The aims of this study were (1) to determine if there are differences in nociceptive withdrawal reflex thresholds (NWR-T) and electrical pain thresholds (EP-T) before and after SCS; and (2) to establish if these differences are related to psychological factors associated with chronic pain. Seventeen volunteers with chronic neuropathic pain participated in the experiment. Electrical stimuli were applied to assess the NWR-T and the EP-T. In addition, psychological factors (ie, pain characteristics, depression, anxiety, and disability indexes) were also recorded. The NWR-T and EP-T were assessed with the SCS system off (at least 8 h before the experiment), and then reassessed 1 hour after the SCS system was turned on. Ongoing pain intensity ratings decreased (P=0.018), whereas the NWR-T increased (P=0.028) after the SCS was turned on, whereas no significant difference was found for EP-T (P=0.324...Continue Reading

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Citations

Mar 12, 2018·Pain Practice : the Official Journal of World Institute of Pain·Andrei D SdrullaSrinivasa N Raja
Sep 25, 2018·Neuromodulation : Journal of the International Neuromodulation Society·Vishwanath SankarasubramanianScott F Lempka
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Aug 23, 2019·Bioelectronic Medicine·Jacob CaylorImanuel Lerman
Jan 31, 2020·Regional Anesthesia and Pain Medicine·W Michael HootenM Hassan Murad
Aug 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Robert D GrahamScott F Lempka

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Methods Mentioned

BETA
PCA
pharmacotherapy

Software Mentioned

PLS
NWR
SPSS
SIMCA
O2PLS
OPLS
P +

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