Dynamic changes of IL-2/IL-10, sFas and expression of Fas in intestinal mucosa in rats with acute necrotizing pancreatitis.

World Journal of Gastroenterology : WJG
Sheng-Chun DangBei Zhu

Abstract

To investigate dynamic changes of serum IL-2, IL-10, IL-2/IL-10 and sFas in rats with acute necrotizing pancreatitis. To explore the expression of Fas in intestinal mucosa of rats with acute necrotizing pancreatitis (ANP). A total of 64 Sprague-Dawley (SD) rats were randomly divided into two groups: normal control group (C group), ANP group (P group). An ANP model was induced by injection of 50 g/L sodium taurocholate under the pancreatic membrane. Normal control group received isovolumetric injection of 9 g/L physiological saline solution using the same method. The blood samples of the rats in each group were obtained via superior mesenteric vein to measure levels of IL-2, IL-10, sFas and calculate the value of IL-2/IL-10. The levels of IL-2, IL-10 and sFas were determined by ELISA. The severity of intestinal mucosal injury was evaluated by pathologic score. The expression of Fas in intestinal mucosal tissue was determined by immunohistochemistry staining. Levels of serum IL-2 were significantly higher in P group than those of C group (2.79 +/- 0.51 vs 3.53 +/- 0.62, 2.93 +/- 0.89 vs 4.35 +/- 1.11, 4.81 +/- 1.23 vs 6.94 +/- 1.55 and 3.41 +/- 0.72 vs 4.80 +/- 1.10, respectively, P < 0.01, for all) and its reached peak at 6 h. L...Continue Reading

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Citations

Jun 15, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Qi-ming XueNing Li
Oct 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Daixing ChenXianlong Ling
Jul 19, 2013·Digestive Diseases and Sciences·Yueqiu QinSien Song
May 23, 2012·Gastroenterology Research and Practice·Shengchun DangJianxin Zhang
Dec 1, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Pascaline FontehMartin Brand
Nov 23, 2019·Cytokine & Growth Factor Reviews·Zhiqiang LiJan G D'Haese

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