PMID: 39748Jan 1, 1979

Dynamic changes of serum gamma-glutamyl transferase in chronic alcoholism

Enzyme
F HornerA Malkin

Abstract

Elevated serum gamma-glutamyl transferase (GGT) levels were found in 29% of 155 chronic alcoholics undergoing detoxification treatment. Alkaline phosphatase (AP) was increased in 16%, alanine aminotransferase--SGPT (ALT) in 12% of the patients, while 23% had elevations of either AP or ALT or both. Of the foregoing parameters, GGT was the best single indicator of liver involvement. In course of the follow-ups GGT/ALT correlation improved, but GGT/AP correlation deteriorated. In 9 patients, abstinence during follow-up was associated with progressive decrease in previously elevated serum GGT. Because of its unique sensitivity, GGT may be useful as a screening and/or monitoring aid in alcoholism.

References

Apr 28, 1984·British Medical Journal·B PeterssonB Hood
Dec 1, 1991·Journal of the American College of Nutrition·C S Lieber
Jan 1, 1980·CRC Critical Reviews in Clinical Laboratory Sciences·D M Goldberg
Feb 12, 1983·British Medical Journal·R Penn, D J Worthington

Related Concepts

Pyruvate Dehydrogenase Phosphatase Deficiency
Gamma-glutamyl transferase
Alkaline Phosphatase Measurement
Alkaline Phosphatase
Alcohol Abuse
Metabolic Detoxication, Drug
Alanine Transaminase
Alcoholics
Liver
Alanine Aminotransferase Measurement

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