Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models

Biological Psychiatry
Rupali SrivastavaAkira Sawa

Abstract

Mitochondria play a crucial role in neuronal function, especially in energy production, the generation of reactive oxygen species, and calcium signaling. Multiple lines of evidence have suggested the possible involvement of mitochondrial deficits in major psychiatric disorders, such as schizophrenia and bipolar disorder. This review will outline the current understanding of the physiological role of mitochondria and their dysfunction under pathological conditions, particularly in psychiatric disorders. The current knowledge about mitochondrial deficits in these disorders is somewhat limited because of the lack of effective methods to dissect dynamic changes in functional deficits that are directly associated with psychiatric conditions. Human neuronal cell model systems have been dramatically developed in recent years with the use of stem cell technology, and these systems may be key tools for overcoming this dilemma and improving our understanding of the dynamic changes in the mitochondrial deficits in patients with psychiatric disorders. We introduce recent discoveries from new experimental models and conclude the discussion by referring to future perspectives. We emphasize the significance of combining studies of human neuro...Continue Reading

Citations

Apr 27, 2019·Bipolar Disorders·Logan BorgeltCaleb M Adler
Nov 23, 2019·Schizophrenia Bulletin·Federico E TurkheimerAnthony C Vernon
Dec 24, 2018·Frontiers in Behavioral Neuroscience·Anke Hoffmann, Dietmar Spengler
Feb 25, 2020·Annual Review of Clinical Psychology·Teresa E DanielsAudrey R Tyrka
Nov 23, 2019·Physiological Research·M Ľupták, J Hroudová
Mar 10, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Ho NamkungAkira Sawa
Dec 9, 2020·Psychiatry Research·Khethelo R XuluSian M J Hemmings
May 19, 2018·Journal of Pharmacological Sciences·Sedona LockhartMinae Niwa

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