Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors

Journal of Medicinal Chemistry
Benoît M R LiénardChristopher J Schofield

Abstract

The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM. The study exemplifies the utility of protein-MS for screening dynamic mixtures of potential enzyme-inhibitors.

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Citations

Jan 24, 2012·Journal of Medicinal Chemistry·Esther C Y WoonChristopher J Schofield
Apr 16, 2011·Chemical Communications : Chem Comm·Dong-Hua LiYun-Bao Jiang
Jan 13, 2010·Clinical Microbiology Reviews·Sarah M Drawz, Robert A Bonomo
Mar 19, 2014·Future Medicinal Chemistry·Derek A NicholsYu Chen
Jul 1, 2009·Analytical Biochemistry·Jasmin MecinovićChristopher J Schofield
Sep 14, 2016·ACS Infectious Diseases·Mariano M GonzálezAlejandro J Vila
Apr 30, 2017·Chemical Science·Guo-Bo LiChristopher J Schofield
May 29, 2012·Angewandte Chemie·Marina DemetriadesChristopher J Schofield
Sep 12, 2018·Chemistry : a European Journal·Priska FreiBeat Ernst
Jul 8, 2008·Chembiochem : a European Journal of Chemical Biology·Cécile ClavaudChristophe Dugave
Sep 16, 2008·Chemistry : a European Journal·Mads Corvinius Nielsen, Trond Ulven
Oct 15, 2009·Chembiochem : a European Journal of Chemical Biology·Duncan E ScottAlessio Ciulli
Feb 22, 2011·Chemistry : a European Journal·Marinha dF CapelaAnne Petitjean
Jul 12, 2012·Chemistry : a European Journal·Alexandra J ClipsonMichael F Greaney
Jul 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renjie Huang, Ivanhoe K H Leung
May 16, 2017·ChemMedChem·Laurent SevailleJean-François Hernandez
Apr 24, 2018·Trends in Pharmacological Sciences·Lin-Cheng JuMichael W Crowder
Aug 1, 2013·Journal of Medicinal Chemistry·Sander S van BerkelChristopher J Schofield
Oct 29, 2020·ACS Omega·Andrea Canal-Martín, Ruth Pérez-Fernández

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