Dynamic connectivity and the effects of maturation in youth with attention deficit hyperactivity disorder

Network Neuroscience
N de Lacy, Vince D Calhoun

Abstract

The analysis of time-varying connectivity by using functional MRI has gained momentum given its ability to complement traditional static methods by capturing additional patterns of variation in human brain function. Attention deficit hyperactivity disorder (ADHD) is a complex, common developmental neuropsychiatric disorder associated with heterogeneous connectivity differences that are challenging to disambiguate. However, dynamic connectivity has not been examined in ADHD, and surprisingly few whole-brain analyses of static functional network connectivity (FNC) using independent component analysis (ICA) exist. We present the first analyses of time-varying connectivity and whole-brain FNC using ICA in ADHD, introducing a novel framework for comparing local and global dynamic connectivity in a 44-network model. We demonstrate that dynamic connectivity analysis captures robust motifs associated with group effects consequent on the diagnosis of ADHD, implicating increased global dynamic range, but reduced fluidity and range localized to the default mode network system. These differentiate ADHD from other major neuropsychiatric disorders of development. In contrast, static FNC based on a whole-brain ICA decomposition revealed solel...Continue Reading

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Citations

Apr 16, 2020·Frontiers in Neuroscience·Tahereh S ZarghamiFariba Bahrami
Aug 14, 2020·Social Cognitive and Affective Neuroscience·Armin IrajiVince D Calhoun
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Jul 22, 2021·Journal of Neural Engineering·Maliheh AhmadiArdalan Aarabi
Nov 16, 2021·Frontiers in Neural Circuits·Hae-Jeong ParkJiyoung Kang

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Software Mentioned

GIG
ICA
SPM12
MANCOVAN
Group ICA of fMRI Toolbox ( GIFT )
AFNI
GIFT
3dDespike
Neurosynth

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