Dynamic contrast-enhanced CT in patients treated with sorafenib and erlotinib for non-small cell lung cancer: a new method of monitoring treatment?

European Radiology
Joline S W LindEgbert F Smit

Abstract

We investigated the feasibility of serial dynamic contrast-enhanced computed tomography (DCE-CT) in patients with advanced/metastatic non-small cell lung cancer (NSCLC) receiving anti-angiogenic (sorafenib) and anti-EGFR (erlotinib) treatment, and correlated tumour blood flow (BF) with treatment outcome. DCE-CTs were performed at baseline and 3 and 6 weeks after starting treatment. Tumour BF, calculated with the maximum slope method, and percentage change were measured in 23 patients (14 male; median age 59 years). Tumour BF was compared at baseline and weeks 3 and 6; the relation with RECIST/Crabb response and progression-free survival (PFS) was assessed. Mean tumour perfusion decreased from 39.2 ml/100 g/min at baseline to 15.1 ml/100 g/min at week 3 (p < 0.001) and 9.4 ml/100 g/min at week 6 (p < 0.001). Tumour perfusion was lower in RECIST and Crabb responders versus non-responders at week 3 (4.2 versus 17.7 ml/100 g/min, p = 0.03) and week 6 (0 versus 13.4 ml/100 g/min, p = 0.04). Patients with a decrease larger than the median at week 6 tended to have a longer PFS (7.1 versus 5.7 months, p = 0.06). Serial DCE-CTs are feasible in patients with NSCLC and demonstrated a significant decrease in tumour BF following sorafenib/e...Continue Reading

References

Oct 1, 1989·The British Journal of Radiology·W Panzer, M Zankl
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 15, 2001·Journal of Computer Assisted Tomography·U TateishiK Miyasaka
May 2, 2002·International Journal of Dermatology·Vivian ZemelmanA Kirschbaum
Aug 21, 2002·Academic Radiology·Yoshito TsushimaKeigo Endo
Sep 3, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Therasse
Dec 10, 2002·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·G Stamm, H D Nagel
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James P ThomasGeorge Wilding
Aug 5, 2004·Investigational New Drugs·Henry Q XiongJames L Abbruzzese
Oct 1, 2004·The British Journal of Radiology·K A Miles
Nov 26, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Stephen B Fox, Adrian L Harris
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettGregory Y Lauwers
Feb 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Quan-Sing NgPeter J Hoskin
Jun 7, 2007·American Journal of Clinical Oncology·Michael I KoukourakisCostantinos Simopoulos
Oct 2, 2007·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Gulgun Yilmaz OvaliYüksel Pabuscu
Dec 7, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuan LiYan-Rong Lu
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Simon J CrabbScott A Laurie
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Aug 5, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George R BlumenscheinMartin Reck
Sep 8, 2009·Academic Radiology·Stephan P KloskaWalter Heindel
Apr 17, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joline S W LindEgbert F Smit

❮ Previous
Next ❯

Citations

Mar 1, 2012·European Radiology·K A MilesUNKNOWN Experimental Cancer Medicine Centre Imaging Network Group
Jul 15, 1988·Biochemical and Biophysical Research Communications·W Nellen, U Saur
Nov 13, 1985·Biochimica Et Biophysica Acta·R B GuyerR A Deering
Oct 19, 1993·Biochimica Et Biophysica Acta·D KnechtC Scherczinger
Jun 28, 2011·AJR. American Journal of Roentgenology·Chaan S NgRazelle Kurzrock
Dec 21, 2012·AJR. American Journal of Roentgenology·Roberto García-FigueirasAntonio Gómez-Caamaño
Apr 4, 2014·World Journal of Gastroenterology : WJG·Koichi HayanoDushyant V Sahani
Jan 7, 2014·Radiation Oncology·Clemens C CyranMaximilian Niyazi
Apr 25, 2012·Journal of Biomedicine & Biotechnology·Yanni HuHong Zhang
Jun 17, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·Q Q TeoQ S Ng
Nov 16, 2011·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Roberto García FigueirasPeter L Choyke
Dec 8, 2014·Academic Radiology·Agostino GibaldiAlessandro Bevilacqua
Nov 7, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J de CastroJ Ferreirós
Jan 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thomas HenzlerGerald Schmid-Bindert
Sep 24, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sonja SudarskiThomas Henzler
Jun 22, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mizuki NishinoBruce E Johnson
Aug 6, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P-G QiaoG-J Li
Feb 1, 2011·Academic Radiology·Mizuki NishinoAnnick D Van den Abbeele
Dec 3, 2013·Clinical Physiology and Functional Imaging·S W HardersB M Fischer
Mar 27, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A WellerN M deSouza
Jun 28, 2015·European Journal of Radiology·Wolfgang M ThaissKonstantin Nikolaou
Mar 27, 2015·Investigative Radiology·Hyungjin KimHans-Ulrich Kauczor

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT00722969

Software Mentioned

Basama Perfusion
Vinci

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.