Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: pharmacokinetic analysis and correlation to tumor histomorphology

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Christine EllingsenEinar K Rofstad

Abstract

Biomarkers that can predict the outcome of treatment accurately are needed for treatment individualization in advanced carcinoma of the uterine cervix. The potential of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was investigated in the present preclinical study. CK-160 and TS-415 human cervical carcinoma xenografts were subjected to DCE-MRI at 1.5T using a spatial resolution of 0.23×0.47×2.0mm(3). Parametric images of K(trans) (the volume transfer constant of Gd-DTPA) and v(e) (the extravascular extracellular volume fraction) were produced by pharmacokinetic analysis of the DCE-MRI data and compared with the histomorphology of the imaged tissue. Analysis of small homogeneous tumor regions showed that K(trans), but not v(e), differed significantly between parenchymal tissue, connective tissue, and necrotic tissue, consistent with the vascularity of these compartments. However, strong correlations between K(trans) and the fractional volume of the compartments could not be detected for larger tumor regions, primarily because the majority of the voxels represented a chaotic mixture of parenchymal, connective, and necrotic tissue. The potential of DCE-MRI in providing detailed information on the histomorphology o...Continue Reading

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Citations

May 5, 2011·Journal of Biomedicine & Biotechnology·Xiangyu Yang, Michael V Knopp
May 23, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kjersti V LundEinar K Rofstad
Nov 16, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christine EllingsenEinar K Rofstad
Aug 16, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristine GulliksrudEinar K Rofstad
May 23, 2014·International Journal of Radiation Biology·Claudia PeitzschIna Kurth
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Erlend K F AndersenEirik Malinen
Jul 1, 2017·Acta Oncologica·Catherine S WegnerEinar K Rofstad
Jul 12, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zhaoguang ZhangRongrong Zhao

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