Dynamic-contrast-enhanced magnetic resonance imaging of cirrhotic liver parenchyma: A comparison between gadolinium-diethylenetriamine pentaacetic acid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid

Journal of the Chinese Medical Association : JCMA
Chun-Yi LinRan-Chou Chen

Abstract

The newly developed magnetic-resonance-imaging (MRI) hepatocyte-specific contrast agent, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has different excretion pathways from the conventional MRI contrast agent, gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). In this study, we compare the enhancement effect of the liver and renal parenchyma between these two contrast agents for patients with liver cirrhosis. We retrospectively included 49 consecutive patients with liver cirrhosis who underwent Gd-DTPA- and Gd-EOB-DTPA-enhanced MRIs within 3 months. We measured the signal intensity of the liver and kidney, and calculated the enhancement ratio (ER) in the arterial phase, portal venous phase, and venous phase (VP). We also calculated a delayed phase (DP) when Gd-DTPA was used, and a hepatocyte phase (HP) when Gd-EOB-DTPA was used. The ERs were compared between the two contrast agents. The effect of liver function on the ERs was also evaluated. The ER of the liver with Gd-EOB-DTPA was significantly higher than with Gd-DTPA in the VP (p = 0.01) and in the HP/DP (p = 0.01). The ER of the kidney in the DP with Gd-DTPA was significantly higher than in the HP with Gd-EOB-DTPA (p < 0.001). The ERs of ...Continue Reading

References

Jan 8, 2005·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hun-Kyu RyeomDuk-Sik Kang
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nam Kyung LeeHyung Il Seo
Dec 5, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Melanie K SealeDushyant V Sahani
Jun 23, 2010·AJR. American Journal of Roentgenology·Kristina I RingeElmar M Merkle
Jun 23, 2010·AJR. American Journal of Roentgenology·Irene CruiteClaude B Sirlin
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Mar 31, 2012·Magnetic Resonance Imaging·Atsushi HigakiKatsuyoshi Ito
Jun 16, 2012·Insights Into Imaging·José Traila CamposJin-Young Choi
Jul 26, 2013·AJR. American Journal of Roentgenology·Ji Yeon KimMoon-Gyu Lee

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