Dynamic contrast enhanced MRI-derived parameters are potential biomarkers of therapeutic response in bladder carcinoma

European Journal of Radiology
Camille ChakibaNadine Houédé

Abstract

To evaluate the performance of dynamic contrast enhanced (DCE) magnetic resonance (MR) imaging to assess the histological response after chemotherapy on bladder carcinoma. From 2008 to 2010, 12 patients presenting localized urothelial carcinoma of the bladder were prospectively evaluated by DCE-MR imaging before and after two courses of cisplatin-based neoadjuvant chemotherapy. Size and thickness of tumours were measured. Relative enhancement at the arterial (rSI35s) and venous phases (rSI80s) of each tumour was obtained. Histological response was assessed and outcomes were recorded. Histological examination after neoadjuvant chemotherapy concluded as pathological complete response (pCR) for 6 out of 12 patients. Five patients developed recurrences (4/6 no pCR and 1/6 pCR). Significant differences, between before and after treatment, were found for patients with complete pathological response after chemotherapy for all MR quantitative values. Tumours decreased in size and thickness (both P=0.03). After treatment, rSI80s was significantly different between pCR and non-pCR patients (P=0.04) with a cut-off value of 40%. For this cut-off, sensitivity, specificity and accuracy were 83.33%. Similar recurrence free survivals were obta...Continue Reading

References

Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Jan 1, 1950·Cancer·W J YOUDEN
Dec 24, 2004·AJR. American Journal of Roentgenology·Aylin TekesDavid Bluemke
Mar 7, 2006·World Journal of Urology·John P Stein, Donald G Skinner
Feb 17, 2009·World Journal of Urology·Martine PloegLambertus A Kiemeney
Aug 31, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Uday B PatelGina Brown
Sep 20, 2011·Clinical Radiology·A RajeshM J G Bankart
Mar 15, 2012·International Journal of Radiation Oncology, Biology, Physics·Soichiro YoshidaKazunori Kihara
Jan 9, 2013·Journal of the National Cancer Institute·Michael L MarinovichStefano Ciatto
May 23, 2014·AJR. American Journal of Roentgenology·Robbert J de HaasJurgen J Fütterer

❮ Previous
Next ❯

Citations

Dec 29, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tom J N HermansBas W G van Rhijn
Aug 26, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R A TownerR E Hurst
Oct 30, 2016·Future Oncology·Emanuele Neri, Daniele Regge
Mar 1, 2020·Journal of Magnetic Resonance Imaging : JMRI·Iztok CaglicTristan Barrett
Sep 18, 2020·Journal of Magnetic Resonance Imaging : JMRI·Valeria PanebiancoYoshifumi Narumi
Nov 21, 2018·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Ebru SalmanogluMathew L Thakur
Feb 26, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M RouprêtA Méjean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.