Dynamic contrast-enhanced MRI for the detection of prostate cancer: meta-analysis

AJR. American Journal of Roentgenology
Cher Heng TanVikas Kundra

Abstract

The purpose of this study was to systematically review and meta-analyze dynamic contrast-enhanced MRI (DCE-MRI) for the detection of prostate cancer in comparison with standard evaluation with T2-weighted imaging. A PubMed electronic database search for the terms "dynamic contrast-enhanced," "prostate," and "MRI" was completed for articles up to September 17, 2013. All included studies had histopathologic correlation. Two by two contingency data were constructed for each study. A binormal bayesian ROC model was used to estimate and compare sensitivity, specificity, and AUC among eligible modalities. Both DCE-MRI (0.82-0.86) and diffusion-weighted MRI (DWI) (0.84-0.88) yielded significantly better AUC than T2-weighted imaging (0.68-0.77). Moreover, partial AUC for the combination of DCE-MRI, DWI, and T2-weighted imaging was improved significantly (0.111; 0.103-0.119) when compared with DCE-MRI alone (0.079; 0.072-0.085) and T2-weighted imaging alone (0.079; 0.074-0.084) but not DWI alone (0.099; 0.091-0.108). Sensitivity and specificity were similar among the four modalities. DCE-MRI improves AUC of tumor detection overall compared with T2-weighted imaging alone. Methods for DCE-MRI analysis require standardization, but visual a...Continue Reading

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Citations

Jan 28, 2016·Abdominal Radiology·Andreas G WibmerHebert Alberto Vargas
May 20, 2016·Abdominal Radiology·Rose M BermanBaris Turkbey
Sep 15, 2015·Future Oncology·Andreas G WibmerHedvig Hricak
Nov 26, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Constantinos ZamboglouAnca-Ligia Grosu
Apr 5, 2016·Urologic Oncology·Ely R FelkerLeonard S Marks
Jun 17, 2015·Current Urology Reports·Andrea S KieransAndrew B Rosenkrantz
Aug 16, 2016·Abdominal Radiology·Elmira HassanzadehClare M Tempany
Aug 18, 2016·Future Oncology·Samuel BorofskyMyles Taffel
May 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Leonardo Kayat BittencourtRomulo Varella de Oliveira
Apr 19, 2020·Abdominal Radiology·Michele ScialpiStefano Signore
Jul 23, 2020·Nature Reviews. Urology·David Eldred-EvansHashim U Ahmed
Jul 16, 2017·Cold Spring Harbor Perspectives in Medicine·Eric T MillerRobert E Reiter
Jan 30, 2019·European Radiology Experimental·Rossano GiromettiChiara Zuiani
May 5, 2020·BioTechniques·Murali K RavooriVikas Kundra

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