Abstract
To test the hypothesis that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides a useful in vivo measure of passive blood retinal barrier permeability surface area product (BRB PS) in experimental diabetic retinopathy. BRB PS (cm(3)/min) was measured using DCE-MRI and Gd-DTPA (MW 590 Da) in urethane-anesthetized control rats, sodium iodate-treated rats, rats receiving intravitreally injected human serum albumin (HSA) or vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), or in rats that were diabetic for 2, 4, 6, or 8 months. Sodium iodate-treated rats exhibited an eightfold increase (P < 0.05) in BRB PS compared to that in control animals. Furthermore, in iodate-treated rats, the average vitreous signal enhancement was linearly dependent on Gd-DTPA dose (r = 0.91, P < 0.0001). Six hours postinjection, VEGF/VPF-treated rats exhibited a threefold increase in BRB PS (P < 0.05) compared to eyes injected with HSA. In 2-, 4-, and 6-month diabetic rats, BRB PS was not significantly different (P > 0.05) from control BRB PS values. After 8 months of diabetes, a twofold increase (P < 0.05) in PS over control PS values was found. DCE-MRI demonstrated that the BRB becomes leaky immediately befor...Continue Reading
Citations
Dec 24, 2011·Diabetologia·L A MaileD Clemmons
Jul 29, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hirotaka ItakuraMasahiko Kurabayashi
Jun 10, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Bruce A Berkowitz, Robin Roberts
Aug 4, 2007·Pharmaceutical Research·Stephanie H KimRobert J Lutz
Jan 8, 2011·Journal of Integrative Neuroscience·Kevin C ChanEd X Wu
Jul 27, 2007·Investigative Ophthalmology & Visual Science·Bruce A BerkowitzAlgis J Vingrys
Jan 19, 2012·PloS One·Bruce A BerkowitzRobin Roberts
Oct 23, 2010·Medical Physics·Haoyu WangJiani Hu
Feb 18, 2014·Survey of Ophthalmology·J Emanuel Ramos de CarvalhoReinier O Schlingemann
Feb 16, 2008·Experimental Diabetes Research·Timothy S Kern
Sep 8, 2015·Progress in Retinal and Eye Research·Bruce A BerkowitzRobin Roberts
Apr 5, 2012·Journal of Pharmaceutical Sciences·S Kevin LiJing-huei Lee
Nov 8, 2011·Magnetic Resonance Imaging·Yuto KashiwagiKohji Abe
Sep 21, 2010·Journal of the Neurological Sciences·J M Wardlaw
Jun 12, 2010·Experimental Eye Research·Xin LiuEun-Kee Jeong
Jan 14, 2010·Journal of Neuroscience Methods·Jeffrey WisardJohn M Nickerson
Jul 22, 2008·Experimental Eye Research·Kevin C ChanEd X Wu
Sep 30, 2008·NMR in Biomedicine·Gary L TrickBruce A Berkowitz
Mar 5, 2009·Annals of Neurology·Joanna M WardlawBaljean Dhillon
Jan 11, 2008·NMR in Biomedicine·S Kevin LiEun-Kee Jeong
Aug 30, 2008·NMR in Biomedicine·Bruce A Berkowitz, Robin Roberts
Mar 2, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yi ZhangTimothy Q Duong
May 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qing WangJunjie Chen
Dec 21, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yen-Yu I ShihTimothy Q Duong
May 30, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Timothy Q Duong
Apr 15, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Irene TsiapaThomas G Maris
Apr 1, 2011·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Timothy Q Duong
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·Joanna M WardlawMartin S Dennis
Apr 3, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Junjie ChenSheng-Kwei Song
May 19, 2019·Pharmaceutics·Ana Castro-BaladoAnxo Fernández-Ferreiro
Feb 5, 2021·Current Eye Research·Thoralf NiendorfOliver Stachs
Sep 11, 2020·Diabetes·Francesco TecilazichMara Lorenzi