Dynamic contrast-enhanced MRI of malignant pleural mesothelioma: a comparative study of pharmacokinetic models and correlation with mRECIST criteria

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Martina Vivoda TomšičKatarina Šurlan Popovič

Abstract

Malignant pleural mesothelioma (MPM) is a rare and aggressive thoracic malignancy that is difficult to cure. Dynamic contrast-enhanced (DCE) MRI is a functional imaging technique used to analyze tumor microvascular properties and to monitor therapy response. Purpose of this study was to compare two tracer kinetic models, the extended Tofts (ET) and the adiabatic approximation tissue homogeneity model (AATH) for analysis of DCE-MRI and examine the value of the DCE parameters to predict response to chemotherapy in patients with MPM. This prospective, longitudinal, single tertiary radiology center study was conducted between October 2013 and July 2015. Patient underwent DCE-MRI studies at three time points: prior to therapy, during and after cisplatin-based chemotherapy. The images were analyzed using ET and AATH models. In short-term follow-up, the patients were classified as having disease control or progressive disease according to modified response evaluation criteria in solid tumors (mRECIST) criteria. Receiver operating characteristic curve analysis was used to examine specificity and sensitivity of DCE parameters for predicting response to therapy. Comparison tests were used to analyze whether derived parameters are interch...Continue Reading

References

Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangPaolo Paoletti
Feb 5, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J Byrne, A K Nowak
Sep 21, 2006·NMR in Biomedicine·Susan M Galbraith
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Josephine H NaishGeoffrey J M Parker
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stephanie B DonaldsonDavid L Buckley
May 27, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Gunnar BrixFrederik Wenz
Aug 18, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lucy E Kershaw, Hai-Ling Margaret Cheng
Oct 6, 2011·Journal of Magnetic Resonance Imaging : JMRI·Tong San KohChoon Hua Thng
May 16, 2013·NMR in Biomedicine·Steven P Sourbron, David L Buckley
Jul 17, 2013·Journal of Magnetic Resonance Imaging : JMRI·Joseph R LedsamSteven P Sourbron
Aug 25, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Samuel G ArmatoAshoke Khanwalkar
Oct 8, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lin ChengDow-Mu Koh
Dec 11, 2017·The Annals of Thoracic Surgery·Sahar A SaddoughiShanda H Blackmon

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Methods Mentioned

BETA
imaging techniques
biopsy

Software Mentioned

MedCalc
Olea Medical
mRECIST
AATH
MPM

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