Dynamic Contrast-Enhanced Ultrasound Identifies Microcirculatory Alterations in Sepsis-Induced Acute Kidney Injury

Critical Care Medicine
Alexandre LimaCan Ince

Abstract

We developed quantitative methods to analyze microbubble kinetics based on renal contrast-enhanced ultrasound imaging combined with measurements of sublingual microcirculation on a fixed area to quantify early microvascular alterations in sepsis-induced acute kidney injury. Prospective controlled animal experiment study. Hospital-affiliated animal research institution. Fifteen female pigs. The animals were instrumented with a renal artery flow probe after surgically exposing the kidney. Nine animals were given IV infusion of lipopolysaccharide to induce septic shock, and six were used as controls. Contrast-enhanced ultrasound imaging was performed on the kidney before, during, and after having induced shock. Sublingual microcirculation was measured continuously using the Cytocam on the same spot. Contrast-enhanced ultrasound effectively allowed us to develop new analytical methods to measure dynamic variations in renal microvascular perfusion during shock and resuscitation. Renal microvascular hypoperfusion was quantified by decreased peak enhancement and an increased ratio of the final plateau intensity to peak enhancement. Reduced intrarenal blood flow could be estimated by measuring the microbubble transit times between the ...Continue Reading

References

Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J SzebeniC R Alving
May 23, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Jonathan R LindnerSanjiv Kaul
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Wei WangRobert W Schrier
Sep 16, 2003·Critical Care Medicine·Michael PiagnerelliMichel Vanhaeverbeek
Oct 3, 2003·Cardiovascular Research·Kirsten PetersC James Kirkpatrick
Mar 3, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ravindra L MehtaUNKNOWN Acute Kidney Injury Network
Aug 24, 2007·The New England Journal of Medicine·J Gary Abuelo
Sep 12, 2007·Critical Care : the Official Journal of the Critical Care Forum·Daniel De BackerCan Ince
Mar 28, 2008·Critical Care : the Official Journal of the Critical Care Forum·Filippo MarianoGiovanni Camussi
Jun 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Didier PayenUNKNOWN Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators
Dec 26, 2008·Critical Care : the Official Journal of the Critical Care Forum·Jiri ChvojkaMartin Matejovic
Aug 29, 2009·Clinical Hemorheology and Microcirculation·Christian Greis
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
Apr 22, 2010·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·C HoeffelJ-M Correas
Nov 26, 2010·Ultrasound in Medicine & Biology·A NeedlesF S Foster
May 19, 2011·Critical Care : the Official Journal of the Critical Care Forum·Antoine SchneiderRinaldo Bellomo
Oct 28, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jan BenesMartin Matejovic
Feb 4, 2012·Intensive Care Medicine·Clive N MayRinaldo Bellomo
Jul 31, 2012·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·C F DietrichF Piscaglia
Jun 8, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Paweena SusantitaphongUNKNOWN Acute Kidney Injury Advisory Group of the American Society of Nephrology
Oct 16, 2013·Critical Care Medicine·Christoph LangenbergRinaldo Bellomo
Dec 3, 2013·Critical Care : the Official Journal of the Critical Care Forum·Matthieu LegrandDidier Payen
Jan 25, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Martijn J C DaneTon J Rabelink
Mar 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincenzo CantaluppiLuigi Biancone
May 23, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bulent ErginCan Ince
Dec 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Antoine G SchneiderRinaldo Bellomo
Aug 2, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lara Zafrani, Can Ince
Aug 13, 2015·Intensive Care Medicine Experimental·Antoine G SchneiderRinaldo Bellomo
Oct 21, 2015·Clinical Hemorheology and Microcirculation·Sam HutchingsEmrys Kirkman
Mar 12, 2016·American Journal of Respiratory and Critical Care Medicine·Matthew J MaidenRinaldo Bellomo

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Citations

Aug 8, 2018·Oncology Research and Treatment·Katrin Hardoerfer, Elisabeth Jentschke
Apr 26, 2019·Current Opinion in Critical Care·Daniel De Backer
Jan 7, 2020·Clinical Hemorheology and Microcirculation·Pan PanXiaoting Wang
Jul 12, 2019·Journal of Applied Physiology·Gonzalo FerraraArnaldo Dubin
Jun 16, 2019·Critical Care : the Official Journal of the Critical Care Forum·John J MariniJean-Louis Vincent
Jun 23, 2020·Clinical Hemorheology and Microcirculation·Romeo Martini
Oct 13, 2020·Current Opinion in Critical Care·Jonathan Suarez, Laurence W Busse
Oct 20, 2020·Current Opinion in Critical Care·Nicholas M Selby, Jacques Duranteau
Apr 27, 2021·American Journal of Physiology. Renal Physiology·Jianni HuangShougang Zhuang
Jun 1, 2021·Frontiers in Veterinary Science·Edward S Cooper, Deborah C Silverstein

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