Dynamic contrast-enhanced ultrasound parametric imaging for the detection of prostate cancer

BJU International
Arnoud W PostemaHessel Wijkstra

Abstract

To investigate the value of dynamic contrast-enhanced (DCE)-ultrasonography (US) and software-generated parametric maps in predicting biopsy outcome and their potential to reduce the amount of negative biopsy cores. For 651 prostate biopsy locations (82 consecutive patients) we correlated the interpretation of DCE-US recordings with and without parametric maps with biopsy results. The parametric maps were generated by software which extracts perfusion parameters that differentiate benign from malignant tissue from DCE-US recordings. We performed a stringent analysis (all tumours) and a clinical analysis (clinically significant tumours). We calculated the potential reduction in biopsies (benign on imaging) and the resultant missed positive biopsies (false-negatives). Additionally, we evaluated the performance in terms of sensitivity, specificity negative predictive value (NPV) and positive predictive value (PPV) on a per-prostate level. Based on DCE-US, 470/651 (72.2%) of biopsy locations appeared benign, resulting in 40 false-negatives (8.5%), considering clinically significant tumours only. Including parametric maps, 411/651 (63.1%) of the biopsy locations appeared benign, resulting in 23 false-negatives (5.6%). In the per-pro...Continue Reading

References

Jun 18, 2003·Academic Radiology·Patrick M BossuytUNKNOWN STARD Group
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Aug 19, 2011·World Journal of Urology·Martijn SmeengeHessel Wijkstra
Nov 15, 2011·European Urology·Dionysios MitropoulosUNKNOWN European Association of Urology Guidelines Panel
Sep 11, 2012·BJU International·Giovanna RussoHessel Wijkstra
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Citations

Dec 10, 2015·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Stefan G SchalkMassimo Mischi
Dec 23, 2016·European Radiology·Rogier R WildeboerMassimo Mischi
Mar 12, 2016·Biomedical Engineering and Computational Biology·Saradwata Sarkar, Sudipta Das
Mar 14, 2019·Current Opinion in Oncology·Michael AhdootPeter A Pinto
Jul 22, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yun YuanFeng Jiang
Apr 20, 2020·World Journal of Urology·Jean-Michel CorreasJean de la Rosette
Sep 30, 2020·Ultrasound in Medicine & Biology·D Cody MorrisKathryn R Nightingale
Jan 18, 2020·Computer Methods and Programs in Biomedicine·Rogier R WildeboerMassimo Mischi
Apr 10, 2021·Ultrasound in Medicine & Biology·D Cody MorrisKathryn R Nightingale

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