Dynamic CT Evaluation of Tumor Vascularity in Renal Cell Carcinoma

AJR. American Journal of Roentgenology
Jin Hong WangXin Qing Mao

Abstract

The purpose of our study was to evaluate the correlation between the enhancement parameters of dynamic CT; the carcinoma tissue microvessel density (MVD, a hotspot method to provide a histologic assessment of tumor vascularity); and tumor nuclear grade in renal cell carcinomas. Twenty-four patients with histologically diagnosed renal cell carcinoma underwent dynamic enhanced CT. Enhancement parameters, slope of the time-density curve, the density difference before and after tissue enhancement (deltaH), tissue blood ratio (TBR), and area under the time-density curve (AR), were calculated for all lesions. Pathology slides corresponding to the CT plane were stained using mouse antihuman CD34 monoclonal antibody and H and E. Fuhrman nuclear grade was used. Vascular hot spots of microvessels were recorded. Spearman's rank correlation was performed to determine the strength of the relationship between enhancement parameters, MVD determinations, and tumor nuclear grade. MVD with CD34 staining revealed uneven distribution of positively stained vascular endothelial cells in renal cell carcinoma lesions. Heterogeneous distribution of contrast enhancement was seen among and within individual tumors. The tumors appeared as uneven patterns ...Continue Reading

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