Dynamic depth-dependent osmotic swelling and solute diffusion in articular cartilage monitored using real-time ultrasound

Ultrasound in Medicine & Biology
Y P ZhengK Y Zhou

Abstract

The objective of this study was to investigate the feasibility of ultrasonic monitoring for the transient depth-dependent osmotic swelling and solute diffusion in normal and degenerated articular cartilage (artC) tissues. Full-thickness artC specimens were collected from fresh bovine patellae. The artC specimens were continuously monitored using a focused beam of 50 MHz ultrasound (US) during sequential changes of the bathing solution from 0.15 mol/L to 2 mol/L saline, 0.15 mol/L saline, 1 mg/mL trypsin solution, 0.15 mol/L saline, 2 mol/L saline and back to 0.15 mol/L saline. The transient displacements of US echoes from the artC tissues at different depths were used to represent the tissue deformation and the NaCl diffusion. The trypsin solution was used selectively to digest the proteoglycans in artC. It was demonstrated that high-frequency US was feasible for monitoring the transient osmotic swelling, solute transport and progressive degeneration of artC in real-time. Preliminary results showed that the normal bovine patellar artC shrank during the first several minutes and then recovered to its original state in approximately 1 h when the solution was changed from 0.15 mol/L to 2 mol/L saline. Degenerated artC showed neith...Continue Reading

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Citations

Aug 10, 2010·Ultrasound in Medicine & Biology·S G PatilXin Chen
Dec 17, 2011·Science China. Life Sciences·HaiJun NiuYuBo Fan
Jul 14, 2010·Ultrasound in Medicine & Biology·Qing WangXia Guo
Feb 26, 2008·Ultrasound in Medicine & Biology·Qing WangHong-Bin Lu
Jul 6, 2014·BioMed Research International·Sara ManzanoMohamed Hamdy Doweidar
Feb 16, 2006·Osteoarthritis and Cartilage·E M DarlingF Guilak

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