Dynamic designing of microstructures by chemical gradient-mediated growth

Nature Communications
Tae Soup ShimShin-Hyun Kim

Abstract

Shape is one of the most important determinants of the properties of microstructures. Despite of a recent progress on microfabrication techniques, production of three-dimensional micro-objects are yet to be fully achieved. Nature uses reaction-diffusion process during bottom-up self-assembly to create functional shapes and patterns with high complexity. Here we report a method to produce polymeric microstructures by using a dynamic reaction-diffusion process during top-down photolithography, providing unprecedented control over shape and composition. In radical polymerization, oxygen inhibits reaction, and therefore diffusion of oxygen significantly alters spatial distribution of growth rate. Therefore, growth pathways of the microstructures can be controlled by engineering a concentration gradient of oxygen. Moreover, stepwise control of chemical gradients enables the creation of highly complex microstructures. The ease of use and high controllability of this technology provide new opportunities for microfabrication and for fundamental studies on the relationships between shape and function for the materials.

References

Mar 30, 2002·Science·George M Whitesides, Bartosz Grzybowski
Aug 15, 2003·Nature·Pete Vukusic, J Roy Sambles
Apr 11, 2006·Nature Materials·Dhananjay DendukuriPatrick S Doyle
Jul 20, 2006·Journal of the American Chemical Society·Zhihong NieEugenia Kumacheva
Apr 4, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Dhananjay DendukuriPatrick S Doyle
Apr 2, 2008·Journal of the American Chemical Society·Jennifer Y Kelly, Joseph M DeSimone
Mar 23, 2011·Journal of the American Chemical Society·Shin-Hyun KimDavid A Weitz
Jun 10, 2011·Nature Communications·Matthew J HarringtonIngo Burgert
Aug 1, 2012·Journal of the American Chemical Society·Kundan ChaudharyJennifer A Lewis
Feb 16, 2013·Science·Marc André MeyersPo-Yu Chen
May 21, 2013·Science·Wim L NoorduinJoanna Aizenberg
Oct 3, 2013·Chemical Reviews·Samuel Clark LigonRobert Liska
Oct 23, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Ju Hyeon KimSeung-Man Yang
May 6, 2014·Journal of the American Chemical Society·Fuquan Tu, Daeyeon Lee

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Citations

Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jie Fei, Ran Liu
Apr 29, 2016·ACS Applied Materials & Interfaces·Gun Ho LeeShin-Hyun Kim
Apr 4, 2017·Advanced Materials·Soojeong ChoShin-Hyun Kim
Nov 18, 2015·Advanced Materials·Ju Hyeon KimShin-Hyun Kim
Dec 12, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Morteza JeyhaniScott S H Tsai
Jan 12, 2019·Chemical Communications : Chem Comm·Miryam Criado-GonzalezFouzia Boulmedais
May 5, 2017·Biomicrofluidics·Junbeom KimKi Wan Bong
Jun 6, 2017·Nature Communications·Matija LovrakJan H van Esch
Jan 22, 2020·ACS Applied Materials & Interfaces·H GojzewskiG J Vancso

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