Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit.

Neural Systems & Circuits
Hiroyuki KatagiriPierre-Marie Lledo

Abstract

The olfactory bulb (OB) receives and integrates newborn interneurons throughout life. This process is important for the proper functioning of the OB circuit and consequently, for the sense of smell. Although we know how these new interneurons are produced, the way in which they integrate into the pre-existing ongoing circuits remains poorly documented. Bearing in mind that glutamatergic inputs onto local OB interneurons are crucial for adjusting the level of bulbar inhibition, it is important to characterize when and how these inputs from excitatory synapses develop on newborn OB interneurons. We studied early synaptic events that lead to the formation and maturation of the first glutamatergic synapses on adult-born granule cells (GCs), the most abundant subtype of OB interneuron. Patch-clamp recordings and electron microscopy (EM) analysis were performed on adult-born interneurons shortly after their arrival in the adult OB circuits. We found that both the ratio of N-methyl-D-aspartate receptor (NMDAR) to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), and the number of functional release sites at proximal inputs reached a maximum during the critical period for the sensory-dependent survival of newborn ...Continue Reading

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Citations

Sep 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gabriel LepousezPierre-Marie Lledo
Nov 30, 2012·Annual Review of Physiology·Gabriel LepousezPierre-Marie Lledo
Mar 15, 2011·The European Journal of Neuroscience·Antoine Nissant, Marta Pallotto
Apr 24, 2015·Neuron·Gabriel LepousezPierre-Marie Lledo
May 5, 2016·Cold Spring Harbor Perspectives in Biology·Juan SongHongjun Song

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Methods Mentioned

BETA
electron microscopy

Software Mentioned

Reconstruct

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