Dynamic diffusion tensor imaging of spinal cord contusion: A canine model

Journal of Neuroscience Research
Changbin LiuZhentao Zuo

Abstract

This study aimed to explore the dynamic diffusion tensor imaging (DTI) of changes in spinal cord contusion using a canine model of injury involving rostral and caudal levels. In this study, a spinal cord contusion model was established in female dogs using a custom-made weight-drop lesion device. DTI was performed on dogs with injured spinal cords (n=7) using a Siemens 3.0T MRI scanner at pre-contusion and at 3 h, 24 h, 6 weeks and 12 weeks post-injury. The tissue sections were stained for immunohistochemical analysis. Canine models of spinal cord contusion were created successfully using the weight-drop lesion device. The fractional anisotropy (FA) value of lesion epicenter decreased, while the apparent diffusion coefficient (ADC), mean diffusivity (MD), and radial diffusivity (RD) values increased, and the extent of the curve was apparent gradually. The site and time affected the DTI parameters significantly in the whole spinal cord, ADC (site, P < 0.001 and time, P = 0.077, respectively); FA (site, P < 0.001 and time, P = 0.002, respectively). Immunohistological analysis of GFAP and NF revealed the pathologic changes of reactive astrocytes and axons, as well as the cavity and glial scars occurring during chronic SCI. DTI is ...Continue Reading

References

Sep 1, 1987·Radiology·M V KulkarniJ H Harris
Aug 1, 1983·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M Khan, R Griebel
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Jun 1, 1993·Annals of Emergency Medicine·J T Povlishock
Apr 5, 2002·Journal of Neuroscience Research·Alexander G RabchevskyStephen W Scheff
Sep 25, 2002·European Radiology·K HerganT A G M Huisman
Nov 21, 2002·Progress in Brain Research·Wise Young
Apr 5, 2003·Journal of Neurotrauma·William L MaxwellDavid I Graham
Jul 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·V MenetM Giménez y Ribotta
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ulrika WilhelmssonMilos Pekny
Aug 31, 2004·American Journal of Otolaryngology·J Clinton SmithEdward C Smith
Jan 28, 2005·Journal of Neurotrauma·Alun AckeryAndrei Krassioukov
Mar 30, 2005·Brain Research. Brain Research Protocols·Seijun FukudaYasuhiko Shimizu
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Feb 4, 2006·Journal of Neuroscience Research·Aparna A DeoPonnada A Narayana
May 5, 2006·Acta Neurochirurgica. Supplement·F Y ZhaoA Tamura
Jun 30, 2007·Journal of Neurotrauma·David N LoySheng-Kwei Song
Nov 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine L Mac DonaldDavid Brody
Feb 2, 2008·Brain Injury : [BI]·Laura MilesMatilde Inglese
Jul 15, 2009·Spinal Cord·G OnoseK R H von Wild
Dec 25, 2009·Asia-Pacific Journal of Public Health·Wen-Ta ChiuShin-Han Tsai
Jun 16, 2011·Journal of Neurotrauma·Jin-Chong XuMelitta Schachner
Jun 21, 2013·Journal of Neurotrauma·Michael B JirjisBrian D Schmit
Oct 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Feng WangLi Min Chen
Apr 30, 2015·The Neuroradiology Journal·Dalun LeongJames M Provenzale
Aug 11, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mu LinJianhui Zhong

❮ Previous
Next ❯

Citations

Jun 27, 2020·Journal of Neurotrauma·Melissa J LewisNatasha J Olby
Jan 29, 2019·Neural Regeneration Research·Xin ZhangJian-Jun Li
Dec 23, 2020·Journal of Veterinary Internal Medicine·Philippa J JohnsonErica F Barry
Nov 17, 2020·Frontiers in Veterinary Science·Ronaldo C da CostaUNKNOWN Canine Spinal Cord Injury Consortium (CANSORT-SCI)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.