Dynamic distribution of basic fibroblast growth factor during epulis formation: an immunohistochemical study in an enhanced healing process of the gingiva

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M MurataTakashi Saku

Abstract

Basic fibroblast growth factor (bFGF) is thought to play an important role in wound healing. However, its histological localization, both in normal and pathological conditions in the oral mucosa, has not been well documented. We have studied the immunolocalization of bFGF in normal gingiva and gingival epulis specimens corresponding to different organizing stages. In normal gingiva, bFGF was detected in subpopulations of macrophages, mast cells and most endothelial cells in the lamina propria. Granulation tissue in epulides was histopathologically classified into six organizing stages. In stages 1 and 2, a small number of bFGF-positive macrophages was seen at the periphery of ulcer bases. In stages 3 and 4, histologically characterized by prominent capillary proliferation, large numbers of bFGF-positive macrophages and mast cells were located within granulation tissue. A positive reaction for bFGF was also found in some endothelial cells and in myxoedematous stroma that was rich in heparan sulfate proteoglycan. In stages 5 and 6, when fibrosis was accelerated, bFGF-positive macrophages and mast cells decreased in number and were localized only at the periphery of the fibrous tissue. These findings suggest that maximum amounts o...Continue Reading

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Citations

Sep 21, 2007·Photochemistry and Photobiology·Yoshinori NakagishiMakoto Kikuchi
Mar 22, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Reet KamalAbhiney Puri
Mar 27, 2015·Journal of Natural Science, Biology, and Medicine·Reet KamalHans Raj Saini
Apr 14, 2015·Periodontology 2000·Matthias ChiquetDimitris Kletsas
Apr 30, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Maria AndrikopoulouAlexandra Sklavounou
Jan 26, 2010·Pathology, Research and Practice·Shokoufeh Shahrabi FarahaniFiroozan Sadr Ashkevari
Feb 26, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·W M TilakaratneT Saku
Jan 5, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T A RamaM H Fernandes
Nov 16, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Spyridon I VassilopoulosJohn A Vrotsos
Jun 17, 2016·Contemporary Clinical Dentistry·D Radha BharathiT S S Kumar
Oct 23, 2015·International Journal of Dermatology·Osvaldo T Vázquez-MartínezRocío Ortiz-López
Jun 2, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hiroko Ida-YonemochiTakashi Saku
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Apr 2, 2004·European Journal of Oral Sciences·Hiroko Ida-YonemochiTakashi Saku
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Aug 11, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroko UtsunomiyaTakashi Saku
Oct 31, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sachiko OhtakéTakashi Saku

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