PMID: 8594019Nov 1, 1995Paper

Dynamic elastance and tissue resistance of isolated liquid-filled rat lungs

Journal of Applied Physiology
D NavajasMara S Ludwig

Abstract

The effect of the surface forces of the alveolar air-liquid interface on the dynamic behavior of lung tissue was investigated in five isolated liquid-filled rat lungs. The lungs were subjected to 0.04-Hz sinusoidal oscillation (1.5-ml tidal volume) at lung volume (VL) levels ranging from volume at zero pressure (V0) + 4 ml to V0 + 10 ml. Oscillations were performed at each VL after inflation of the lungs from V0. Alveolar pressure (PA) was measured with an alveolar capsule attached to the visceral pleura. Dynamic elastance (Edyn), tissue resistance (Rti), and hysteresivity [eta = Rti omega/Edyn, where omega is angular frequency (2 pi x frequency)] were computed from PA and VL changes. Edyn was 59.6 +/- 4.3 Pa/ml at V0 + 4 ml and varied little up to V0 + 7 ml. Thereafter, Edyn increased markedly with VL, reaching 102 +/- 16 Pa/ml at V0 + 10 ml. No significant difference was found between elastance computed from PA and that computed from pressure recorded at the airway opening. Rti was 35.2 +/- 3.6 Pa.s.ml-1 and exhibited a VL dependence similar to that of Edyn. As a result, eta was 0.16 and did not vary significantly in the explored VL range. We conclude that PA can be reliably measured in the liquid-filled lung by means of alve...Continue Reading

Citations

Jul 23, 2003·Journal of Applied Physiology·Kelly K BrewerBéla Suki
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·M DolhnikoffM S Ludwig
Apr 18, 2009·American Journal of Respiratory and Critical Care Medicine·Dani-Louise DixonAndrew D Bersten
Jun 2, 2000·Journal of Biomechanical Engineering·E Denny, R C Schroter

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