Dynamic evaluation and quantification of microvascularization during degradable starch microspheres transarterial Chemoembolisation (DSM-TACE) of HCC lesions using contrast enhanced ultrasound (CEUS): a feasibility study

Clinical Hemorheology and Microcirculation
Philipp WiggermannE M Jung

Abstract

To evaluate the time dependent changes of microcirculation in hepatocellular carcinoma (HCC) lesions during degradable starch microsphere (DSM)-TACE using contrast enhanced ultrasound (CEUS). A total of 48 CEUS examinations were performed (1-5 MHz, convex probe) in 6 selected patients who underwent DSM-TACE with EmboCept®S for the treatment of HCC lesions. I.v. application of ultrasound contrast media was performed before and 24 hours post embolization. In addition i.a. contrast application was performed via the angiographic catheter right before and after the embolization and during a follow up time of 2 hours every 30 minutes. The capillary circulation of the treated HCC lesions was analyzed and quantitative perfusion analysis was performed using a perfusion software by two experienced radiologists in consensus. A significantly reduced microvascularization was seen right after DSM-TACE in all cases using CEUS. The reduction of PEAK, RBV (regional blood volume) and RBF (regional blood flow) compared to preembolization values was highly significant. Mean PEAK was 34.3 ± 13.1 prior to embolization and 9.4 ± 9.1 post embolization (p < 0.001). Mean RBV was 446.5 ± 122.4 prior to embolization and 70.9 ± 23.8 post embolization (p < ...Continue Reading

Citations

Oct 25, 2014·Ultrasonography·Yong Eun Chung, Ki Whang Kim
Nov 2, 2013·Der Radiologe·D-A Clevert, E M Jung
May 26, 2016·Expert Opinion on Drug Delivery·Dawn Bannerman, Wankei Wan
Mar 5, 2020·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Johannes HauboldJens Theysohn
Aug 21, 2014·Cardiovascular and Interventional Radiology·Claus C PieperKai E Wilhelm
Mar 22, 2016·Hepatic Oncology·Fabrizio ChegaiLorenzo Mannelli
Oct 8, 2015·Clinical Hemorheology and Microcirculation·Liliana ChioreanChristoph F Dietrich
Aug 9, 2020·The Journal of International Medical Research·Kunpeng HuJie Ren
Jun 10, 2020·Cardiovascular and Interventional Radiology·Matthias StecheleFlorian Streitparth

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