Abstract
During embryonic development, E-cadherin mediates intercellular adhesion in a variety of epithelia in a spatio-temporal pattern. We have analyzed the distribution of this cell adhesion molecule in the mouse during odontogenesis, at both mRNA and protein levels, in the mandibular first molars and incisors. E-cadherin was strongly expressed at the bell stage by the cells of the dental organ, and by the pre-secretory ameloblasts and the cells of stratum intermedium at the early mineralization stage. At the onset of enamel secretion, E-cadherin disappeared from the apical pool of the ameloblasts and was later absent from the post-secretory ameloblasts. E-cadherin was also found in Hertwig's root sheath and later in the cells producing acellular cementum. These findings indicate that E-cadherin may be involved in the polarization of the ameloblasts and in the early stages of cementogenesis.
Citations
Sep 9, 2005·Connective Tissue Research·Hirofumi KoikeHideki Tanzawa
Mar 7, 2002·European Journal of Oral Sciences·Yves CamHervé Lesot
Dec 4, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Margarita Zeichner-DavidPablo Bringas
Jan 25, 2012·European Journal of Oral Sciences·John D BartlettCharles E Smith
Aug 13, 2013·Periodontology 2000·Jimin XiongP Mark Bartold
Jul 12, 2013·European Journal of Oral Sciences·Hui XueCarolyn W Gibson
Feb 3, 2015·Clinical Oral Implants Research·Dieter D BosshardtHendrik Terheyden
Nov 26, 2002·Archives of Oral Biology·Nobuko ObaraMasako Takeda
Apr 28, 2012·Developmental Biology·Chun-Ying LiOphir D Klein
Sep 24, 2010·PloS One·John D BartlettZiedonis Skobe
Jun 12, 2002·The American Journal of Pathology·Robert HeymannThimios A Mitsiadis
Apr 29, 2011·Cells, Tissues, Organs·John D BartlettCharles E Smith
Feb 26, 2008·Journal of Dental Research·K TakamoriY Chai
Apr 21, 2005·Journal of Dental Research·D D Bosshardt
Feb 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B C SorkinZ Skobe
Jan 20, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F LézotA Berdal
Nov 9, 2017·Frontiers in Physiology·Mirali PandyaThomas G H Diekwisch