Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Pilar SantistebanKenneth S Zaret

Abstract

While much is known about Groucho corepressors in Drosophila development, less is known about Grg homologs in mammalian embryogenesis. The transcription factors FoxA1 and FoxA2 are redundantly necessary for liver-inductive competence of the endoderm, and recently we found that FoxA factors bind Grg3, recruit the corepressor to FoxA target genes, and cause transcriptional repression, when Grg3 is ectopically expressed in adult liver cell lines that express little or no endogenous Grg. Unexpectedly, we now find that Grg1 and Grg3 mRNAs are co-expressed with FoxA factors in the foregut endoderm, prior to liver differentiation, though only Grg3 protein is expressed there. Grg3 mRNA and protein are extinguished at the onset of liver differentiation. Lentiviral delivery of Grg3 to explants of foregut endoderm suppresses liver gene induction. We suggest that Grg expression in the endoderm helps suppress the liver program and find that endodermal competence involves a balance between activators and corepressors.

References

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Jan 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C Leon, C G Lobe
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Jun 17, 2005·Nature·Catherine S LeeKlaus H Kaestner
Apr 25, 2007·BMC Developmental Biology·Alistair J WattStephen A Duncan
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Dec 6, 2008·Science·Kenneth S Zaret, Markus Grompe

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Citations

Nov 8, 2011·Genes & Development·Kenneth S Zaret, Jason S Carroll
Mar 10, 2011·Development·Donghun ShinDidier Y R Stainier
Jul 20, 2010·Current Opinion in Genetics & Development·Stephen T Smale
Jul 2, 2010·Current Opinion in Genetics & Development·Klaus H Kaestner
Jun 26, 2013·Nature Reviews. Cancer·Eric W-F LamChuay-Yeng Koo
Dec 6, 2019·Thyroid : Official Journal of the American Thyroid Association·Caroline Serrano-NascimentoPilar Santisteban
Jun 18, 2015·Development·Miriam GordilloValerie Gouon-Evans
Sep 13, 2013·Journal of Proteome Research·Erin KaltenbrunFrank L Conlon

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