Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system

The Journal of Comparative Neurology
Claire BaconGudrun Rappold

Abstract

We investigated the expression of the three known Slit-Robo GTPase activating protein (srGAP) genes in the developing murine nervous system using in situ hybridization. The three genes are expressed during embryonic and early postnatal development in the murine nervous system, showing a distinct pattern of expression in the olfactory system, the eye, forebrain and midbrain structures, the cerebellum, the spinal cord, and dorsal root ganglia, which we discuss in relation to Slit-Robo expression patterns and signaling pathways. We also report srGAP2 expression in zones of neuronal differentiation and srGAP3 in ventricular zones of neurogenesis in many different tissues of the central nervous system (CNS). Compared to srGAP2 and srGAP3, the onset of srGAP1 expression is later in most CNS tissues. We propose that these differences in expression point to functional differences between these three genes in the development of neural tissues.

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Citations

Apr 3, 2012·Journal of Cell Science·Jaeda Coutinho-BuddFranck Polleux
Jan 10, 2013·PloS One·Claudia Figueroa-RomeroEva L Feldman
Feb 25, 2014·Molecular and Cellular Neurosciences·Yun-Kai DaiWei-Lin Jin
Mar 31, 2015·FEBS Letters·Silvia Wuertenberger, Yvonne Groemping
Nov 23, 2011·American Journal of Medical Genetics. Part a·Hirotomo SaitsuNaomichi Matsumoto
Nov 26, 2009·Journal of Cellular Physiology·Ruth G TatevossianDenise Sheer
Jul 22, 2011·Small GTPases·Lukas Jakob Neukomm, Jason Michael Kinchen
Aug 26, 2014·Asian Pacific Journal of Tropical Medicine·Quan-Peng ZhangXi-Nan Yi
Nov 7, 2012·Mechanisms of Development·Claire BaconGudrun A Rappold
Nov 4, 2017·Journal of Cell Science·Bethany Lucas, Jeff Hardin
Jun 19, 2019·Neurotoxicity Research·Hong-Qi LiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 8, 2014·Physiological Reviews·Shiro SuetsuguTadaomi Takenawa
Jul 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert WaltereitDusan Bartsch
Mar 31, 2015·Genes & Cancer·Clifford H ShinJames P Robinson
May 27, 2010·Development·Athena R YpsilantiAlain Chédotal

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