Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis

Oncogene
Siwen DangPeng Hou

Abstract

Hepatitis B virus (HBV) infection is the primary cause of hepatocellular carcinoma (HCC). Zinc-finger protein 382 (ZNF382), which belongs to zinc-finger protein family, has been documented to be downregulated in certain types of cancer. However, its role in HCC remains largely unknown. In this study, we demonstrated that ZNF382 expression was significantly elevated in HBV-infected liver cirrhosis tissues relative to HBV-negative normal liver tissues at protein levels, but not at mRNA levels, and was positively correlated with the levels of HBV DNA and hepatitis B virus X protein (HBx). Further studies revealed that ZNF382 was a target of miR-6867, and HBx promoted the translation of ZNF382 during HBV chronic infection through Erk-mediated miR-6867 inhibition. In addition, our data showed that ZNF382 was frequently downregulated by promoter methylation in HBV-related HCCs relative to HBV-infected liver cirrhosis tissues, and decreased expression of ZNF382 was strongly correlated with poor survival in early-stage HCC patients. Functional studies demonstrated that ZNF382 was a potent tumor suppressor in HCC cells through inhibiting cell proliferation, colony formation, migration, invasion, and tumorigenic potential in nude mice, a...Continue Reading

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Citations

Nov 5, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shi ChenXi Zeng
Nov 6, 2020·BioMed Research International·Xiang-Hui NingJin-Jian Yang
Aug 3, 2021·Frontiers in Oncology·Pin ZhaoShaojun Xing
Sep 8, 2021·Environmental Toxicology·Yuan LiChunrong Dong

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Methods Mentioned

BETA
PCR
flow cytometry
transfection
xenograft
immunoprecipitation
ChIP

Software Mentioned

miRanda
miRDB
TargetScan
SPSS

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