Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Galphao implicate significant roles of Galphao-GRIN1 signaling in nervous system.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Ikuo MasuhoTakayoshi Inoue

Abstract

GRIN1 (Gprin 1) is a signaling molecule coexpression of which with constitutively active form of Galphao can stimulate neurite extensions in Neuro2a cells, yet its in vivo roles remain elusive. Here, we examine expression profiles of GRIN1 during mouse development by in situ hybridization (ISH) and immunohistochemistry. ISH analysis revealed that GRIN1 expression was limited to the nervous system at all developmental stages tested: in the central nervous system, GRIN1 expression occurred within the entire embryonic mantle zones, while it became restricted to sets of nuclei at postnatal to adult stages. Immunohistochemistry using a GRIN1-specific antibody demonstrated that GRIN1 colocalized with Galphao at neuronal dendrites and axons, but it was not detected in glial cells. These results suggest that Galphao-GRIN1 pathway could mediate significant roles in neuronal migration and differentiation at embryonic stages and exert functions in wiring and/or maintenance of specific neural circuitries at postnatal to adult stages.

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Citations

Sep 12, 2012·Molecular Psychiatry·E SkafidasC Pantelis
Jun 8, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yong ZhuGuixing Qiu
Feb 2, 2017·Neuroscience and Biobehavioral Reviews·Esther A R NibbelingDineke S Verbeek
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Aug 21, 2010·Developmental Medicine and Child Neurology·Ying-Xue DingLi-Ping Zou
Feb 13, 2020·Science Signaling·Camille N PujolSéverine Chaumont-Dubel
Oct 7, 2020·Animals : an Open Access Journal From MDPI·Xueying ZhangXiangpeng Yue
Dec 1, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Weidong ZhouPeifei Li

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