Dynamic functional imaging of brain glucose utilization using fPET-FDG

NeuroImage
Marjorie VillienJacob M Hooker

Abstract

Glucose is the principal source of energy for the brain and yet the dynamic response of glucose utilization to changes in brain activity is still not fully understood. Positron emission tomography (PET) allows quantitative measurement of glucose metabolism using 2-[(18)F]-fluorodeoxyglucose (FDG). However, FDG PET in its current form provides an integral (or average) of glucose consumption over tens of minutes and lacks the temporal information to capture physiological alterations associated with changes in brain activity induced by tasks or drug challenges. Traditionally, changes in glucose utilization are inferred by comparing two separate scans, which significantly limits the utility of the method. We report a novel method to track changes in FDG metabolism dynamically, with higher temporal resolution than exists to date and within a single session. Using a constant infusion of FDG, we demonstrate that our technique (termed fPET-FDG) can be used in an analysis pipeline similar to fMRI to define within-session differential metabolic responses. We use visual stimulation to demonstrate the feasibility of this method. This new method has a great potential to be used in research protocols and clinical settings since fPET-FDG imag...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F SchuierL Sokoloff
Oct 5, 1986·Nature·P T FoxD C Van Essen
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M ReivichA Anand
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R E CarsonP Herscovitch
Apr 11, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff
Aug 7, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S G HasselbalchO B Paulson
Jun 17, 2006·Annual Review of Neuroscience·Marcus E Raichle, Mark A Mintun
May 13, 2010·NeuroImage·Jonathan R PolimeniLawrence L Wald
Sep 10, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hsiao-Ying WeyTimothy Q Duong
Jan 12, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nicole CauchonJohan E van Lier
Jan 17, 2012·NeuroImage·Richard B Buxton
Jan 18, 2012·NeuroImage·Bruce Fischl
Mar 1, 2012·NeuroImage·Richard D Hoge
Mar 8, 2013·NeuroImage·Joseph B MandevilleMarc D Normandin
Jun 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christin Y SanderJoseph B Mandeville

❮ Previous
Next ❯

Citations

Dec 9, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael Michaelides, Yasmin L Hurd
Dec 22, 2015·Seminars in Nuclear Medicine·Michael S PlaczekJacob M Hooker
Jan 13, 2015·European Journal of Nuclear Medicine and Molecular Imaging·P WernerO Sabri
Oct 1, 2016·Brain and Behavior·Christopher E BauerStan Majewski
Aug 19, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·D L BaileyT Beyer
Nov 15, 2017·Brain Structure & Function·Andreas HahnRupert Lanzenberger
Aug 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christin Y SanderBruce R Rosen
Jan 4, 2019·Human Brain Mapping·Zhaolin ChenGary F Egan
Jun 6, 2019·Annual Review of Biomedical Engineering·Jacob M Hooker, Richard E Carson
Oct 11, 2019·Brain Imaging and Behavior·Christoph KrausRupert Lanzenberger
Jan 18, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jingwan FangHuafeng Liu
Feb 14, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yohan BoillatRolf Gruetter
Sep 16, 2017·Current Opinion in Neurology·Igor YakushevChristian Habeck
May 3, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gregory P BartonAlan B McMillan
Oct 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Antoine Verger, Eric Guedj
Jun 26, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Fang LiuXiaoli Lan
Sep 1, 2016·Translational Stroke Research·Emiri T MandevilleJoseph B Mandeville
Aug 14, 2019·Frontiers in Neuroscience·Tadashi Watabe, Jun Hatazawa
Mar 15, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christin Y SanderHsiao-Ying Wey
Jul 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Marco PaganiLuca Ostacoli
Jul 30, 2019·BioMed Research International·Agostino ChiaravallotiOrazio Schillaci
Feb 23, 2020·Frontiers in Neurology·Tatjana Traub-WeidingerEkaterina Pataraia
Feb 13, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rohit MaharMatthew E Merritt
Oct 23, 2020·Scientific Data·Sharna D JamadarGary F Egan
Mar 13, 2020·NeuroImage·Shenpeng LiZhaolin Chen
Feb 8, 2021·Pharmacology, Biochemistry, and Behavior·Matthew A BoehmMichael Michaelides
Apr 4, 2021·Journal of Clinical Medicine·Philip A CorradoKara N Goss
Mar 4, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexandre SavioIgor Yakushev
Jul 9, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Andreas HahnRupert Lanzenberger
Jun 4, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lucas RischkaAndreas Hahn
Jun 1, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andreas HahnRupert Lanzenberger
Jul 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Lars Jonasson StiernmanAnna Rieckmann
Aug 19, 2021·Proceedings of the National Academy of Sciences of the United States of America·Manu S Goyal, Abraham Z Snyder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.