Dynamic gene expression in the song system of zebra finches during the song learning period

Developmental Neurobiology
Christopher R OlsonClaudio V Mello

Abstract

The brain circuitry that controls song learning and production undergoes marked changes in morphology and connectivity during the song learning period in juvenile zebra finches, in parallel to the acquisition, practice and refinement of song. Yet, the genetic programs and timing of regulatory change that establish the neuronal connectivity and plasticity during this critical learning period remain largely undetermined. To address this question, we used in situ hybridization to compare the expression patterns of a set of 30 known robust molecular markers of HVC and/or area X, major telencephalic song nuclei, between adult and juvenile male zebra finches at different ages during development (20, 35, 50 days post-hatch, dph). We found that several of the genes examined undergo substantial changes in expression within HVC or its surrounds, and/or in other song nuclei. They fit into broad patterns of regulation, including those whose expression within HVC during this period increases (COL12A1, COL 21A1, MPZL1, PVALB, and CXCR7) or decreases (e.g., KCNT2, SAP30L), as well as some that show decreased expression in the surrounding tissue with little change within song nuclei (e.g. SV2B, TAC1). These results reveal a broad range of mole...Continue Reading

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Citations

Dec 23, 2016·Scientific Reports·Jaana OikkonenChakravarthi Kanduri
Apr 5, 2018·BMC Genomics·Peter V LovellClaudio V Mello
Jun 24, 2018·The European Journal of Neuroscience·Shin Hayase, Kazuhiro Wada
Oct 25, 2017·The Journal of Comparative Neurology·Christina HeroldKarl Zilles
Aug 4, 2019·BMC Genomics·Samantha R FriedrichClaudio V Mello
Jan 11, 2021·Hormones and Behavior·Ha Na ChoeErich D Jarvis

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