Dynamic instability and migration modes of collective cells in channels

Journal of the Royal Society, Interface
Shao-Zhen LinXi-Qiao Feng

Abstract

Migrating cells constantly experience geometrical confinements in vivo, as exemplified by cancer invasion and embryo development. In this paper, we investigate how intrinsic cellular properties and extrinsic channel confinements jointly regulate the two-dimensional migratory dynamics of collective cells. We find that besides external confinement, active cell motility and cell crowdedness also shape the migration modes of collective cells. Furthermore, the effects of active cell motility, cell crowdedness and confinement size on collective cell migration can be integrated into a unified dimensionless parameter, defined as the cellular motility number (CMN), which mirrors the competition between active motile force and passive elastic restoring force of cells. A low CMN favours laminar-like cell flows, while a high CMN destabilizes cell motions, resulting in a series of mode transitions from a laminar phase to an ordered vortex chain, and further to a mesoscale turbulent phase. These findings not only explain recent experiments but also predict dynamic behaviours of cell collectives, such as the existence of an ordered vortex chain mode and the mode selection under non-straight confinements, which are experimentally testable acro...Continue Reading

References

May 20, 1998·Biophysical Journal·G ForgacsM S Steinberg
Sep 27, 1993·Physical Review Letters·S W MorrisG Ahlers
Aug 7, 1995·Physical Review Letters·T VicsekO Shochet
Jan 16, 2003·Cell·Barry Lubarsky, Mark A Krasnow
Jul 9, 2005·Science·Ingmar H RiedelJonathon Howard
Sep 5, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Arnold H SzpornDavid E Burstein
Jul 29, 2008·Biochemical and Biophysical Research Communications·Q S LiC T Lim
Dec 17, 2008·Nature·Carlos Carmona-FontaineRoberto Mayor
Jun 24, 2009·Nature Reviews. Molecular Cell Biology·Peter Friedl, Darren Gilmour
Apr 20, 2010·Trends in Cell Biology·Roberto Mayor, Carlos Carmona-Fontaine
Apr 21, 2010·The Journal of Cell Biology·Jacqueline M BenjaminW James Nelson
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·David Moxey, Dwight Barkley
May 21, 2010·Physical Review Letters·Thomas E AngeliniDavid A Weitz
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Thomas E AngeliniDavid A Weitz
Jul 22, 2011·Nature·Brenton D HoffmanMartin A Schwartz
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kandice TannerMina J Bissell
Jul 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sri Ram Krishna VedulaBenoît Ladoux
Aug 3, 2012·Nature Cell Biology·Peter FriedlJeffrey E Segall
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Henricus H WensinkJulia M Yeomans
Sep 25, 2012·Nature Reviews. Molecular Cell Biology·Denise J MontellMichelle Starz-Gaiano
Oct 16, 2012·Science·Martin BehrndtCarl-Philipp Heisenberg
Oct 23, 2012·Nature Nanotechnology·Marija PlodinecCora-Ann Schoenenberger
Jan 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Markus BasanHerbert Levine
Jun 21, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Kevin DoxzenChwee Teck Lim
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Edouard HannezoJean-Francois Joanny
Jan 15, 2014·Biophysical Journal·Olivier Cochet-EscartinPhilippe Marcq
Mar 13, 2014·Nature Materials·Daniel J CohenMichel M Maharbiz
Jun 5, 2014·Biophysical Journal·Alexander G FletcherStanislav Y Shvartsman
Sep 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Brian A CamleyWouter-Jan Rappel
Oct 9, 2014·Biophysical Journal·Bo Li, Sean X Sun
Jun 23, 2015·Annual Review of Biophysics·Bin ChenHuajian Gao
Jul 22, 2015·Physical Review Letters·Felix J SegererJoachim O Rädler
Dec 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Simon GarciaNir S Gov
Mar 19, 2016·Physical Review Letters·Brian A CamleyWouter-Jan Rappel
Sep 1, 2014·Nature Physics·Agustí BruguésXavier Trepat
Nov 4, 2016·Nature Reviews. Molecular Cell Biology·Brian Stramer, Roberto Mayor
Jan 9, 2017·Journal of Biomechanics·Shao-Zhen LinXi-Qiao Feng
Jan 31, 2017·Nature Materials·Chiara MalinvernoGiorgio Scita
Mar 11, 2017·Reports on Progress in Physics·Vincent Hakim, Pascal Silberzan
May 17, 2017·Nature Communications·Amin DoostmohammadiJulia M Yeomans
Jul 1, 2017·PLoS Computational Biology·Daniel L BartonRastko Sknepnek
Apr 1, 2016·Physical Review. X·Dapeng BiM Lisa Manning
Apr 26, 2018·Soft Matter·Fabio GiavazziM Cristina Marchetti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
B GalantiD Segel
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Pilhwa Lee, Charles Wolgemuth
© 2021 Meta ULC. All rights reserved