Dynamic interactions of gas exchange, body mass, and progressive exercise in children

Medicine and Science in Sports and Exercise
Dan M CooperShlomit Radom-Aizik

Abstract

Cardiopulmonary exercise testing (CPET) is increasingly used as a biomarker of fitness in children. Maximal or peak values remain the most common variables obtained in CPET, but these physiologically challenging high-intensity work rates (WR) are often not achieved. We hypothesized that interactions of gas exchange, heart rate (HR), and WR CPET variables (slopes) could yield useful mechanistic and clinical insights that might enhance the clinical utility of CPET in children. We further hypothesized that the dependence of the slope on body mass could be predicted by the first-principle analysis of body size and physiological response. One hundred and sixty-nine healthy participants (8-18 yr old, body mass index <95th percentile, 82 females) underwent dual x-ray absorptiometry scan to estimate lean body mass (LBM) and performed a ramp-type progressive cycle ergometry exercise protocol with a breath-by-breath measurement of gas exchange. Linear regression was used to calculate the slopes among VO2, VCO2, VE, HR, and WR. ΔWR/ΔHR (r = 0.87) and ΔVO2/ΔHR (r = 0.96) were strongly correlated with VO2peak, whereas ΔVO2/ΔWR (r = 0.42) and ΔVE/ΔVCO2 (r = -0.51) were mildly correlated with peak values. LBM was more highly correlated with t...Continue Reading

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Citations

Aug 12, 2014·Clinical and Translational Science·Naveen AshishAmy Taylor
Oct 16, 2015·European Journal of Preventive Cardiology·Bart C BongersTim Takken
Jan 27, 2017·Children·Paolo T PianosiHan C G Kemper
Apr 28, 2019·Pediatric Exercise Science·Dan M Cooper
May 8, 2019·Scandinavian Journal of Medicine & Science in Sports·Kim D LuDan M Cooper
Dec 21, 2018·Pediatric Exercise Science·Bareket Falk, Raffy Dotan

Related Concepts

Cardiopulmonary Exercise Test
Pulse Rate
Dioxygen
Physical Fitness
Pulmonary Gas Exchange
Exercise, Isometric
Body Mass Index Procedure
Biological Markers
Exercise Stress Test
Heart Rate

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