PMID: 9178240Jun 1, 1997Paper

Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
J B MandevilleR M Weisskoff

Abstract

In vivo effective relaxation rates in normal rat liver were evaluated for four dextran coated iron oxide agents: monocrystalline iron oxide nanocolloid (MION) with a mean particle diameter of 3.9 nm, a polycrystalline agent (PION) with a larger mean diameter of 12 nm, and these two agents labeled with the asialofetuin (ASF) protein for high hepatocytic receptor binding affinity (MION-ASF and PION-ASF). Using echo planar imaging at 2 Tesla, dose response was measured with measured with high temporal resolution for 3 h after injection of agent, and by comparing with relaxivities in vitro and in brain, dominant in vivo contrast phenomena were elucidated. While transverse relaxivity for PION-ASF exceeded that for MION-ASF by almost a factor of 2 in solution, relaxation rates in vivo became equivalent. Liver relaxation using non-ASF agents was consistent with rapid water exchange between vascular and extravascular compartments, which dominated relaxation as a result of agent accumulation in Kupffer cells.

References

Mar 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·P ReimerR Weissleder
Jan 1, 1991·Magnetic Resonance Imaging·D PouliquenP Jallet
Dec 1, 1990·AJR. American Journal of Roentgenology·R WeisslederT J Brady
May 1, 1989·Magnetic Resonance Imaging·P A Hardy, R M Henkelman
Feb 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S MajumdarJ C Gore
Nov 1, 1988·Magnetic Resonance Imaging·L JosephsonD D Stark
Feb 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A VillringerT J Brady
Jan 1, 1993·Magnetic Resonance Imaging·B K SchafferR Weissleder
Mar 1, 1995·Journal of Computer Assisted Tomography·E R WisnerR W Katzberg
Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M WeisskoffB R Rosen
Mar 1, 1994·Investigative Radiology·T Bach-GansmoA Hemmingsson
Jan 1, 1993·Magnetic Resonance Imaging·D PouliquenP Jallet
May 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T ShenT J Brady
May 1, 1996·Bioconjugate Chemistry·T T ShenR Weissleder
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M DonahueB R Rosen

❮ Previous
Next ❯

Citations

Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·B E Van BeersA M Smith
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleR M Weisskoff
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J B MandevilleR M Weisskoff
Feb 25, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Bradley P SuttonGregory A Miller
Sep 27, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinjin ZhangMichael Garwood
Dec 21, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tae KimSeong-Gi Kim
Nov 21, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Philip K LiuChristina H Liu
Mar 29, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C C Quarles, K M Schmainda
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanbing LuYihong Yang
Nov 14, 2007·Chembiochem : a European Journal of Chemical Biology·Si-Han WuChung-Yuan Mou
Feb 19, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Y SuhYoung R Kim
Jan 23, 2014·The Analyst·Lionel MauriziHeinrich Hofmann
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J J MarotaJ B Mandeville
May 17, 2000·Journal of Magnetic Resonance Imaging : JMRI·K E KellarS H Koenig
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bianca Elena-Beatrice CrețuVera Balan
Oct 28, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanbing LuJames S Hyde

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.