Dynamic Metabolic State of Tissue Resident CD8 T Cells

Frontiers in Immunology
Špela Konjar, Marc Veldhoen

Abstract

In the past years, there have been significant advances in the understanding of how environmental conditions alone or in conjunction with pathogen invasion affect the metabolism of T cells, thereby influencing their activation, differentiation, and longevity. Detailed insights of the interlinked processes of activation and metabolism can contribute to major advances in immunotherapies. Naive and memory T cells circulate the body. In a quiescent state with low metabolic demands, they predominantly use oxidative phosphorylation for their energy needs. Recognition of cognate antigen combined with costimulatory signals results in a proliferative burst and effector molecule production, requiring rapid release of energy, achieved via dynamically reprogramming metabolic pathways. After activation, most T cells succumb to activation induced cell death, but few differentiate into memory T cells. Of note, some memory T cells permanently occupy tissues without circulating. These, tissue resident T cells are predominantly CD8 T cells, maintained in a metabolic state distinct from naïve and circulating memory CD8 T cells with elements similar to effector CD8 T cells but without undergoing proliferative burst or secreting immune mediators. T...Continue Reading

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Citations

Aug 23, 2020·Metabolites·Luis Gil-de-GómezOlimpio Montero
Nov 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shawna K BrookensMark R Boothby
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Dec 18, 2020·Frontiers in Immunology·Ali AminiPaul Klenerman
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Jul 13, 2021·Frontiers in Immunology·Jie ZhuBin Qu
Sep 7, 2021·Pharmaceutical Patent Analyst·Hermann Am Mucke
Oct 6, 2021·Mucosal Immunology·Leandro BarrosMarc Veldhoen

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