Dynamic microglial modulation of spatial learning and social behavior

Brain, Behavior, and Immunity
Luisa TorresStella E Tsirka

Abstract

Microglia are active players in inflammation, but also have important supporting roles in CNS maintenance and function, including modulation of neuronal activity. We previously observed an increase in the frequency of excitatory postsynaptic current in organotypic brain slices after depletion of microglia using clodronate. Here, we describe that local hippocampal depletion of microglia by clodronate alters performance in tests of spatial memory and sociability. Global depletion of microglia by high-dose oral administration of a Csf1R inhibitor transiently altered spatial memory but produced no change in sociability behavior. Microglia depletion and behavior effects were both reversible, consistent with a dynamic role for microglia in the regulation of such behaviors.

References

Apr 3, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R YirmiyaJ Weidenfeld
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Nov 15, 2006·Learning & Memory·Fiona E HarrisonMichael P McDonald
May 22, 2007·CNS & Neurological Disorders Drug Targets·G Rajkowska, J J Miguel-Hidalgo
Nov 21, 2007·Nature Neuroscience·Bahareh AjamiFabio M V Rossi
Aug 15, 2008·Neuron·Mounira Banasr, Ronald S Duman
Sep 23, 2008·Rejuvenation Research·N Ron-HarelM Schwartz
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroaki WakeJunichi Nabekura
Mar 9, 2010·CNS & Neurological Disorders Drug Targets·Carol A Colton, Donna M Wilcock
Feb 5, 2011·Behavioural Brain Research·Tomoko Uekita, Kazuo Okanoya
Mar 16, 2011·Journal of Visualized Experiments : JoVE·Oksana Kaidanovich-BeilinJames R Woodgett
Jul 23, 2011·Science·Rosa C PaolicelliCornelius T Gross
Aug 17, 2011·International Journal of Environmental Research and Public Health·Andrew D Kraft, G Jean Harry
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Noreen BukhariStella E Tsirka
Nov 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Theodore P NicolaidesC David James
Nov 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin T RogersCarmelina Gemma
Nov 24, 2011·Frontiers in Molecular Neuroscience·Oksana Kaidanovich-Beilin, James Robert Woodgett
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nicholas H VarvelMathias Jucker
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maki HoshikoEtienne Audinat
Jan 22, 2013·Nature Neuroscience·Katrin KierdorfMarco Prinz
Feb 9, 2013·PloS One·Kyungmin JiStella E Tsirka
Mar 26, 2013·Nature Neuroscience·Masaki UenoToshihide Yamashita
Nov 8, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michal SchwartzAlexandre Prat
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ada C Felix-Ortiz, Kay M Tye
Jan 30, 2014·Annual Review of Immunology·Debasis NayakDorian B McGavern
Feb 28, 2014·Nature·Frederick L Hitti, Steven A Siegelbaum
Apr 10, 2014·Nature Reviews. Neuroscience·Marco Prinz, Josef Priller
Jul 22, 2014·Glia·Ishani DeLara S Collier
Aug 12, 2014·PloS One·Marjolein SluijterThorbald van Hall
Aug 19, 2014·The European Journal of Neuroscience·Erica L Stevenson, Heather K Caldwell
Sep 2, 2014·Neuron·Sara M Szczepanski, Robert T Knight
Sep 12, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dhananjay Bambah-MukkuCristina M Alberini

❮ Previous
Next ❯

Citations

Mar 16, 2016·Brain, Behavior, and Immunity·F Rohan Walker, Raz Yirmiya
Apr 25, 2016·Current Opinion in Neurobiology·Tuan Leng TayMarco Prinz
Apr 23, 2016·The Journal of Physiology·Tuan Leng TayMarie-Ève Tremblay
Nov 24, 2017·Frontiers in Immunology·Sara V Maurer, Christina L Williams
Dec 16, 2017·Developmental Neurobiology·Jonathan W VanRyzinMargaret M McCarthy
Aug 9, 2018·Annual Review of Cell and Developmental Biology·Timothy R HammondBeth Stevens
Feb 5, 2019·CNS Spectrums·Célia FourrierBernhard T Baune
Feb 26, 2020·Journal of Neuroendocrinology·Simone N De LucaSarah J Spencer
Jul 15, 2020·The Journal of Pharmacology and Experimental Therapeutics·Alexandros G Kokkosis, Stella E Tsirka
May 26, 2017·Frontiers in Synaptic Neuroscience·Rosa C Paolicelli, Maria T Ferretti
Jan 23, 2018·Frontiers in Molecular Neuroscience·Tuan Leng TayMarie-Eve Tremblay
Jul 22, 2019·Journal of Neuroinflammation·Scott W McPhersonDale S Gregerson
Oct 28, 2019·Cells·Marcus Augusto-OliveiraMaria Elena Crespo-Lopez
Aug 6, 2020·Frontiers in Cellular Neuroscience·Luting YuYi Qu
Jun 21, 2017·Molecular Brain·Jinming HanXing-Mei Zhang
Jul 10, 2019·Annual Review of Neuroscience·Daniel K WiltonBeth Stevens
Jul 1, 2019·Nature Reviews. Neurology·Amy F Lloyd, Veronique E Miron
Apr 20, 2019·Frontiers in Cellular Neuroscience·Jackson KyleStella E Tsirka
Aug 18, 2018·Molecular Neurobiology·Virendra Bhagawan ChineChi Him Eddie Ma
Apr 23, 2020·Frontiers in Immunology·Anouk Benmamar-BadelAgnieszka Wlodarczyk
Apr 17, 2020·Frontiers in Pharmacology·Pia M Vidal, Rodrigo Pacheco
Mar 1, 2017·Frontiers in Cellular Neuroscience·Sarah Jäkel, Leda Dimou
Jul 5, 2017·Frontiers in Synaptic Neuroscience·Elissa L WongAnia K Majewska
Jul 1, 2020·Neurobiology of Disease·Daniel K Wilton, Beth Stevens
Dec 29, 2020·Neurochemistry International·Samuel DeurveilherKazue Semba
Feb 16, 2021·Neurochemistry International·Katherine PicardMarie-Ève Tremblay
Mar 2, 2021·Neural Regeneration Research·David Graykowski, Eiron Cudaback
Mar 17, 2021·The European Journal of Neuroscience·Jeniffer Sanguino-GómezHarm J Krugers
Jun 16, 2021·Brain Research Bulletin·Chao WangYan Gu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved